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Prediction of human population responses to toxic compounds by a collaborative competition
TLDR
The results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal.
Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures
TLDR
HSCT contrary to conventional treatment leads to a significant ‘correction’ in disease-related molecular signatures after HSCT in comparison to intravenous monthly CYC in 62 participants enrolled in the SCOT study.
β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.
TLDR
It is argued that functional selectivity can be exploited to change the quality of G protein-coupled receptor efficacy in vivo through predominantly separate genomic mechanisms created by largely distinct receptor-signaling networks.
Use artificial neural network to align biological ontologies
TLDR
An artificial neural network approach is taken to learn and adjust weights for semantic aspects learned from a subset of concepts, and thereby support a new ontology alignment algorithm, customized for biological ontologies, with the purpose of avoiding some disadvantages in both rule-based and learning-based aligning algorithms.
Consistent Differential Expression Pattern (CDEP) on microarray to identify genes related to metastatic behavior
TLDR
CDEP is a flexible approach that borrows information from each dataset in a meta-analysis in order to identify genes being differentially expressed consistently, suggesting its robustness and insensitivity to data variation commonly associated with microarray experiments.
Enhancing Hi-C data resolution with deep convolutional neural network HiCPlus
TLDR
It is demonstrated that HiCPlus can impute interaction matrices highly similar to the original ones, while only using 1/16 of the original sequencing reads, and it is shown that the models learned from one cell type can be applied to make predictions in other cell or tissue types.
A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis.
TLDR
It is reported here that proliferative responses of Fli-1-deficient naïve B cells to several mitogens were reduced in lupus-prone and control mice, and IL12a and NFAT, known to influence proliferation, were identified as potential mediators of this effect.
Cellular Morphogenesis Under Stress Is Influenced by the Sphingolipid Pathway Gene ISC1 and DNA Integrity Checkpoint Genes in Saccharomyces cerevisiae
TLDR
It is found that the sphingolipid pathway gene ISC1 plays a novel role in determining cellular morphology following HU/MMS treatment, and Mechanistically, the checkpoint regulator Rad53 partially influences isc1Δ cell morphology in a dosage-dependent manner.
Genome3D: A viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional genome
TLDR
Genome3D is a software visualization tool that explores a wide range of structural genomic and epigenetic data within a prescribed three-dimensional physical model of the human genome, and is the first such tool developed that can visualize human genome in three-dimension.
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