Optimising sweet taste in foods.
- W. J. Spillane
- Chemistry
- 1 August 2006
Part 1 Factors affecting sweet taste perception: Stimulation of taste cells by sweet taste compounds Genetic differences in sweet taste perception Children's liking of sweet tastes and its biological…
Structure-activity studies on sulfamate sweeteners.
- G. A. Benson, W. J. Spillane
- ChemistryJournal of Medicinal Chemistry
- 1 July 1976
The structure-activity relationships governing sulfamate sweeteners are reviewed, and the B center of the Shallenberger A-H,B theory of sweetness is best regarded as being -SO3- rather than -SO2- for sulfamates.
Quantitative Structure−Activity Relationship Studies of Sulfamates RNHSO3Na: Distinction between Sweet, Sweet-Bitter, and Bitter Molecules
- M. Drew, Gareth R. H. Wilden, W. J. Spillane, R. M. Walsh, C. A. Ryder, J. Simmie
- Chemistry
- 11 July 1998
Several different QSAR techniques have been applied to sweetness data for 50 sulfamates, RNHSO3Na (21 sweet, 20 sweet-bitter, and 9 bitter). Stepwise discriminant analysis has been used to separate…
Structure-activity studies on sulfamate sweeteners II: semiquantitative structure-taste relationship for sulfamate (RNHSO-3) sweeteners-the role of R.
- W. J. Spillane, G. McGlinchey
- BiologyJournal of Pharmacy and Science
- 1 August 1981
With the use of Corey-Pauling -Koltun space-filling models, measurements of defined parameters (x, y, and z) were made of the R groups in a large number of carbosulfamates, RNHSO-3. The correlation…
Development of structure-taste relationships for monosubstituted phenylsulfamate sweeteners using classification and regression tree (CART) analysis.
- Damien P. Kelly, W. J. Spillane, John Newell
- Mathematics, MedicineJournal of Agricultural and Food Chemistry
- 24 August 2005
Using various methods, predictions were made on the likely tastes of a number of meta compounds and a striking agreement was found between the tree prediction and those given by earlier models, offering a strong vindication of the tree approach.
Basicity of nitrogen–sulphur(VI) compounds. Part 6. Ionization of NN′-di-and N-mono-substituted sulphamides and dihydro-2,1,3-benzothiadiazoline and benzothiadiazine 2,2-dioxides (cyclic sulphamides)
- P. O. Burke, S. McDermott, T. Hannigan, W. J. Spillane
- Chemistry
- 1984
36 Di- and mono- and two tri-substituted sulphamides have been synthesised and their ionization equilibria in base (Schemes 1–3) have been studied. Many of the sulphamides are new materials. The pKa…
Semi-quantitative and quantitative structure–taste relationships for carboand hetero-sulphamate (RNHSO3–) sweeteners
- W. J. Spillane, Maryanne B. Sheahan
- Biology
- 1989
Mapping of the sulphamate receptor site on the basis of the measurements carried out suggests that the carbo- and hetero-sulphamates use different sites to bind, bringing the database of taste-assessed sulphamates reported to over 120 compounds.
Elimination mechanisms in the anilinolysis of sulfamoyl chlorides in chloroform and acetonitrile
- W. J. Spillane, F. A. Mchugh, P. O. Burke
- Chemistry
- 21 April 1998
The kinetics of the reaction of various sulfamoyl chlorides, R1R2NSO2Cl (R1 = Ph, Me, c-C6H11, But, R2 = H and R1 = R2 = Me and R1 = R2 = PhCH2) with anilines in chloroform and acetonitrile have been…
9 – Low-calorie sweeteners
- S. Kemp, W. J. Spillane
- Biology
- 2006
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