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Gastroretentive dosage forms: overview and special case of Helicobacter pylori.
The challenge to develop efficient gastroretentive dosage forms began about 20 years ago, following the discovery of Helicobacter pylori by Warren and Marshall. In order to understand the realExpand
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Interaction of silver nitrate with readily identifiable groups: relationship to the antibacterialaction of silver ions
Microbiologically it was demonstrated that amino acids, e.g. cysteine (CySH), and othercompounds, e.g. sodium thioglycollate, containing thiol groups neutralized the activity of silvernitrate againstExpand
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Mechanisms of action of skin penetration enhancers/retarders: Azone and analogues
Abstract The modifying effect of Azone and five analogues on diffusion of metronidazole through isolated stratum corneum (SC) is reported. All enhance diffusion except N-0915, which is a retarder.Expand
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Epidermal permeability — Penetrant structure relationships: 3. The effect of hydrogen bonding interactions and molecular size on diffusion across the stratum corneum
The permeability coefficient, kp, is the product of partition into (Ksc) and diffusion across (Dh) the stratum corneum (SC). From water, log Ksc = − 0.024 + 0.59 log Koctanol. H-bonding betweenExpand
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Probing the Effect of Vehicles on Topical Delivery: Understanding the Basic Relationship Between Solvent and Solute Penetration Using Silicone Membranes
AbstractPurpose. In the present study we examined the relationship between solvent uptake into a model membrane (silicone) with the physical properties of the solvents (e.g., solubility parameter,Expand
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Epidermal permeability penetrant structure relationships .1. An analysis of methods of predicting penetration of monofunctional solutes from aqueous solutions
Abstract Various multiple linear regressions of human stratum corneum permeability coefficients against solvatochromic parameters, octanol/water and hexane/water partition coefficients wereExpand
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Simple Rules Defining the Potential of Compounds for Transdermal Delivery or Toxicity
AbstractPurpose. Simple rules based on readily accessible physicochemical properties enable identification of solutes that penetrate skin very slowly or rapidly. Methods. Literature in vitro maximalExpand
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Skin permeability data: Anomalous results
Abstract Analysis of published skin permeation data has shown that a few compounds appear to have anomalous skin permeability coefficients. These include penetrants such as naproxen, atropine andExpand
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Medication prescribing and administration in nursing homes
Objective: to examine the key determinants of pharmaco-epidemiology in Australian nursing homes. Design: a cross-sectional survey of medication use in 998 residents in 15 nursing homes in SouthernExpand
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Design, synthesis and characterization of captopril prodrugs for enhanced percutaneous absorption
Most drugs are designed primarily for oral administration, but the activity and stability profiles desirable for this route often make them unsuitable for transdermal delivery. We were thereforeExpand
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