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Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
Importance of the field: The advancement in material design and engineering has led to the rapid development of new materials with increasing complexity and functions. Both non-degradable and… Expand
Developmental toxicity of low generation PAMAM dendrimers in zebrafish.
- T. K. Heiden, E. Dengler, W. J. Kao, W. Heideman, R. Peterson
- Biology, Medicine
- Toxicology and applied pharmacology
- 15 November 2007
Biological molecules and intracellular structures operate at the nanoscale; therefore, development of nanomedicines shows great promise for the treatment of disease by using targeted drug delivery… Expand
In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks
- K. R. Stevens, N. Einerson, Jeanine A Burmania, W. J. Kao
- Materials Science, Medicine
- Journal of biomaterials science. Polymer edition
- 1 January 2002
The in vivo host response to two gelatin-based hydrogel systems of varying crosslinking modalities and loaded with the anti-inflammatory agent dexamethasone sodium phosphate was investigated. Either… Expand
Protein Adsorption to Biomaterials
Within milliseconds after biomaterials come in contact with a biological fluid such as blood, proteins begin to adhere to the surface through a process known as protein adsorption. Protein adsorption… Expand
Transbuccal Delivery of CNS Therapeutic Nanoparticles: Synthesis, Characterization, and In Vitro Permeation Studies.
- Q. Yuan, Y. Fu, W. J. Kao, D. Janigro, H. Yang
- Chemistry, Medicine
- ACS chemical neuroscience
- 16 November 2011
This work utilized polyamidoamine (PAMAM) dendrimer G4.5 as the underlying carrier to construct CNS therapeutic nanoparticles and explored the buccal mucosa as an alternative absorption site for… Expand
Biomimetic material systems for neural progenitor cell-based therapy.
Reconstruction and regeneration of the central nervous system (CNS) following injury is a formidable task. However, cell replacement with transplanted neural progenitor cells (NPC) is a promising… Expand
3D cell entrapment in crosslinked thiolated gelatin-poly(ethylene glycol) diacrylate hydrogels.
- Y. Fu, K. Xu, X. Zheng, A. Giacomin, Adam W Mix, W. J. Kao
- Materials Science, Medicine
The combined use of natural ECM components and synthetic materials offers an attractive alternative to fabricate hydrogel-based tissue engineering scaffolds to study cell-matrix interactions in… Expand
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers
Collagen structure has been shown to influence tumor cell invasion, metastasis and clinical outcome in breast cancer. However, it remains unclear how it affects other solid cancers. Here we utilized… Expand
Thiol-ene-based biological/synthetic hybrid biomatrix for 3-D living cell culture.
Although various cell encapsulation materials are available commercially for a wide range of potential therapeutic cells, their combined clinical impact remains inconsistent. Synthetic materials such… Expand
Recent advances in biomedical polyurethane biostability and biodegradation
This paper summarizes our recent efforts to better understand the effects of antioxidants, the effects of strain-state, mechanistic studies of soft segment cleavage by reactive oxygen radicals, and… Expand