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Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats.

Synthetic AOD9401 has the potential to be developed into a therapeutic agent for the control of obesity and mimicked the effect of the intact growth hormone on diacylglycerol release in adipocytes.
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The conformational and biological analysis of a cyclic anti-obesity peptide from the C-terminal domain of human growth hormone.

Comparison of the conformation of this peptide with residues 177-191 in the native hGH protein X-ray crystal structure indicates that the synthetic peptide retains some structural similarity to the intact protein.
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[Effect of traditional Chinese medicine treatment as maintenance therapy on regulating the serum concentration of sCTLA-4 in patients with advanced non-small-cell lung cancer and its relationship…

  • Y. JiangL. Wu L. Liu
  • Medicine, Biology
    Zhonghua zhong liu za zhi [Chinese journal of…
  • 23 October 2016
Regulating the serum concentration of sCTLA-4 may be one of the mechanisms of TCM maintenance treatment of NSCLC and independent prognostic factors for TTP.
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Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism.

It is indicated that oral administration of AOD-9401 alters lipid metabolism in adipose tissue, resulting in a reduction of weight gain in obese animals, and this small synthetic hGH peptide has potential in the treatment of human obesity.
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[Construction and analysis of competitive endogenous RNA regulatory network related to gastric cancer].

The establishment of ceRNA network for gastric cancer is conducive to further understanding of the molecular biological mechanism and differentially expressed mRNAs were significantly enriched in the biological process (BP) and the mineral absorption pathway.
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Effects of Genetic and Diet‐Induced Obesity on Lipid Metabolism

The lard‐fed mice appeared to have significantly higher body weight in this 34‐day period than that of the other two groups fed on the Normal diet.
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Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide.

Findings support the suggestion that hGH 177-191 is the functional domain of hGH for the antilipogenic actions of the intact hormone both in vivo and in vitro.
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Molecular and cellular actions of a structural domain of human growth hormone ( AOD 9401 ) on lipid metabolism in Zucker fatty rats

Synthetic AOD9401 has the potential to be developed into a therapeutic agent for the control of obesity and mimicked the effect of the intact growth hormone on diacylglycerol release in adipocytes.

The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.

It is demonstrated that the lipolytic actions of both hGH and AOD9604 are not mediated directly through the beta( 3)-AR although both compounds increase beta(3)-AR expression, which may subsequently contribute to enhanced lipolytics sensitivity.
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Subject Index Vol. 53, 2000

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