W. J. Irwin

Publications148
h-index29
Citations2,527
Highly Influential Citations55
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The Effect of Selected Water-Soluble Excipients on the Dissolution of Paracetamol and Ibuprofen
TLDR
The purpose of this investigation was to study the dissolution behavior of paracetamol and ibuprofen in the presence of a range of selected potential excipients, and it was established that both drugs dissolved according to the diffusion-layer model.
Analytical pyrolysis : a comprehensive guide
A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors.
Drug-Delivery by Ion-Exchange: Part IIII: Interaction of Ester Pro-Drugs of Propranolol with Cationic Exchange Resins
TLDR
P pH has little practical effect on the loading efficiency under the conditions used but standardisation of experimental details for the measurement of in vitro liberation profiles must be undertaken.
Phonophoresis - is it a reality?
TLDR
Evidence from the literature is reviewed and it may be concluded that phonophoresis is indeed a reality for certain molecules under certain conditions and that ultrasonic heating is its main though not exclusive mechanism of action.
STABILITY OF DOXORUBICIN, DAUNORUBICIN and EPIRUBICIN IN PLASTIC SYRINGES and MINIBAGS
TLDR
All three drugs were stable for at least 43 days when reconstituted with Water‐for‐Injections BP and stored in polypropylene syringes at4°C and Repeated thawing and re‐freezing of these solutions at ambient temperature did not cause degradation.
Solid-state stability of aspirin in the presence of excipients: kinetic interpretation, modeling, and prediction.
TLDR
The potential use of the melting points of aspirin mixtures in predicting the stability of the drug in such drug-excipient mixtures is demonstrated.
The photochemical stability of cis‐ and trans‐ isomers of tricyclic neuroleptic drugs
  • A. Po, W. J. Irwin
  • Chemistry
    The Journal of pharmacy and pharmacology
  • 1 September 1980
The irradiation of the tranquillizers flupenthixol, clopenthixol and chlorprothixene has been found to induce rapid cis‐trans isomerization. The composition of the photostationary mixture is not that…
Proline uptake by monolayers of human intestinal absorptive (Caco-2) cells in vitro.
Suitability of Enalapril as a Probe of the Dipeptide Transporter System: InVitro and In Vivo Studies
TLDR
In vitro and in vivo results indicated that enalapril is primarily absorbed by a non-saturable, passive diffusion process and it is not a suitable model compound for studying the DTS.
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