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Carbon Storage and Sequestration as Mineral Carbonates
The U.S. Department of Energy has identified mineral sequestration as a promising CO2 sequestration technology option, converting anthropogenic CO2 and magnesium silicates into permanent carbonate…
Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners
- Eva M. Goellner, C. Putnam, W. J. Graham, Christine Rahal, Bin-zhong Li, R. Kolodner
- BiologyNature Structural & Molecular Biology
- 30 July 2018
Two modes of Exo1 recruitment and a peptide module that mediates interactions between Msh2 and other proteins, and they support a model in which Exo 1 functions in MMR by being tethered to the Msh 2–Msh6 complex.
An archaeal RadA paralog influences presynaptic filament formation.
Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System*
- Catherine E. Smith, N. Bowen, W. J. Graham, Eva M. Goellner, Anjana Srivatsan, R. Kolodner
- BiologyThe Journal of Biological Chemistry
- 13 July 2015
Analysis of different mutant proteins demonstrated that both reactions reflect the activation of Mlh1-Pms1 seen in Exo1-independent MMR in vivo, suggesting that the availability of this reconstituted MMR reaction should now make it possible to better study both Exo 1-independent and Exo2-dependent MMR.
Conversion of silicate minerals with carbon dioxide producing environmentally benign and stable carbonates.
Differential radioprotection of normal tissues by hydrophilic chemical protectors.
Studies on the evolution of plasma kinins: Reptilian and avian blood
A recombinase paralog from the hyperthermophilic crenarchaeon Sulfolobus solfataricus enhances SsoRadA ssDNA binding and strand displacement.
The properties of Msh2–Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
- W. J. Graham, C. Putnam, R. Kolodner
- Biology, ChemistryThe Journal of Biological Chemistry
- 20 September 2018
It is suggested that mispair-dependent sliding clamp formation triggers binding of additional Msh2–Msh6 complexes and that further recruitment of additional downstream MMR proteins is required for signal amplification of mispair binding during MMR.