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A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.
It is shown that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid-associated hyperalGESia are markedly attenuated in PKCepsilon mutant mice, but baseline nociceptor thresholds are normal, indicating that PKCEPsilon regulates nocICEptor function and suggesting thatPKCep silon inhibitors could prove useful in the treatment of pain.
The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering
- W. Isenberg, R. McEver, D. Phillips, M. Shuman, D. Bainton
- Biology, Computer ScienceThe Journal of cell biology
- 1 June 1987
Results show that receptor occupancy causes clustering of GPIIb-IIIa in activated platelets in unstimulated platelets.
Sex Steroid Regulation of the Inflammatory Response: Sympathoadrenal Dependence in the Female Rat
- P. Green, S. Dahlqvist, W. Isenberg, H. Strausbaugh, F. Miao, J. Levine
- Biology, MedicineThe Journal of Neuroscience
- 15 May 1999
It is demonstrated that in female but not male rats, estrogen receptor α immunoreactivity is present on medullary but not cortical cells in the adrenal gland, suggesting that regulation of the inflammatory response by female sex steroids is strongly dependent on the sympathoadrenal axis.
Results of a preliminary "blind" study on the presence of the human tumor nucleolar antigen in breast carcinomas, benign breast tumors, and normal breast tissues.
Inhibition of atherosclerosis by fish oil in cholesterol-fed rabbits.
Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits.
Blood vessel invasion and axillary lymph node involvement as prognostic indicators for human breast cancer
Blood vessel invasion is a useful indicator of early recurrence in patients with primary breast cancer and, in combination with node status, is a prognostic indicator with high discriminatory power.
Pathogenesis of Mammary Carcinomas Induced in Rats by 7, 12-Dimethylbenz[a]anthracene
Sex hormones regulate the contribution of PKCε and PKA signalling in inflammatory pain in the rat
Gender differences in PKCε, PKA and NO signalling in epinephrine‐induced hyperalgesia which are oestrogen dependent and appear to be exerted at the level of the β‐adrenergic receptor or the G‐protein to which it is coupled are demonstrated.