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Next-generation genotype imputation service and methods
Improvements to imputation machinery are described that reduce computational requirements by more than an order of magnitude with no loss of accuracy in comparison to standard imputation tools.
Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum.
- R. Krueger, B. Hicks, C. Patrick, S. R. Carlson, W. Iacono, M. McGue
- PsychologyJournal of abnormal psychology
- 1 August 2002
A hierarchical biometric model is presented of the origins of comorbidity among substance dependence, antisocial behavior, and a disinhibited personality style, and it is offered as a novel target for future research to reconcile evidence for general and specific causal factors within the externalizing spectrum.
Neurobehavioral aspects of affective disorders.
A PSYCHOLOGICAL PERS PECTIVE on the Neurobiology of the Behavioral Facilitation System and Implications for Bipolar Affective Disorders.
A reference panel of 64,976 haplotypes for genotype imputation
A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies.
Genome-wide association study identifies 74 loci associated with educational attainment
Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Risk for recurrence in depression.
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Evidence is reported for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission, which provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures.
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.
Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse.
Hyperactivity/impulsivity predicts later substance problems, even after growth in later-emerging CD is considered, whereas inattention alone poses less risk.
Childhood externalizing and internalizing psychopathology in the prediction of early substance use.
The results suggest that externalizing psychopathology is a robust prospective predictor of a variety of early onset substance use behaviors and is systematically related to degree of substance use involvement.