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The multicopper oxidase of Pseudomonas aeruginosa is a ferroxidase with a central role in iron acquisition
Analysis of an mco mutant from the opportunistic pathogen Pseudomonas aeruginosa suggests that an iron acquisition mechanism involving multicopper oxidases may be an important and hitherto unrecognized feature of bacterial pathogenicity. Expand
Chlamydial infection of immune cells: altered function and implications for disease.
The evidence for the growth of Chlamydia in immune cells, particularly monocytes/macrophages and dendritic cells, is reviewed, and how infection may affect the function of these cells is described. Expand
The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis.
- F. Kong, S. Tabrizi, +5 authors J. Hocking
- The Journal of antimicrobial chemotherapy
- 1 May 2015
The efficacy of single-dose azithromycin may be considerably lower than 1 week of doxycycline for treating rectal chlamydia, and robust randomized controlled trials are urgently required. Expand
A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women
- Bryan A. Wee, Mark Thomas, +8 authors W. Huston
- Medicine, Biology
- The Australian & New Zealand journal of…
- 1 June 2018
The authors know very little about the microbiota inhabiting the upper female reproductive tract and how it impacts on fertility, so it is important to understand its role in women's fertility. Expand
Chlamydia trachomatis Genital Tract Infections: When Host Immune Response and the Microbiome Collide.
One hypothesis suggests that C. trachomatis can use its trpBA genes to rescue tryptophan from indole, which is a product of anaerobic members of the genital tract microbiota, and this would enable the chlamydia in these individuals to overcome the host's interferon-γ attempts to eliminate it, resulting in more repeat and/or chronic infections. Expand
Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women
- S. Menon, P. Timms, +6 authors W. Huston
- Biology, Medicine
- Clinical Microbiology Reviews
- 26 August 2015
The existing evidence that host and pathogen genotypes, host hormone status, age of sexual debut, sexual behavior, coinfections, and repeat infections are all likely to be contributory factors in development of infertility is reviewed. Expand
The Epidemiology of Chlamydia trachomatis Organism Load During Genital Infection: A Systematic Review.
- L. Vodstrcil, R. McIver, W. Huston, S. Tabrizi, P. Timms, J. Hocking
- Biology, Medicine
- The Journal of infectious diseases
- 15 May 2015
Chlamydia organism load varies by specimen type and site of sampling, and viable chlam Lydia organism load may be a more important indicator of severity of infection than total load measured by NAAT. Expand
Cyclic‐di‐AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in Lactococcus lactis
GlmM is identified as a c‐di‐AMP level modulating protein and provide a direct connection between c‐ di‐AMP synthesis and peptidoglycan biosynthesis, which is commonly located within the cdaA operon in bacteria. Expand
Uptake and Depuration Kinetics Influence Microplastic Bioaccumulation and Toxicity in Antarctic Krill ( Euphausia superba).
- A. Dawson, W. Huston, +6 authors S. B. Bengtson Nash
- Chemistry, Medicine
- Environmental science & technology
- 3 February 2018
The results support recent findings of limited acute toxicity of ingested microplastics at this trophic level, and suggest sublethal chronic end points should be the focus of further ecotoxicological investigation. Expand
The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 °C
Data demonstrate that chaperone activity may involve functional protease domain and that C. trachomatis HtrA functions as both a chaper one and protease at 37 °C, consistent with the developmental cycle of this obligate intracellular bacterium. Expand