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In vitro mutagenicity of valepotriates
The valepotriates were mutagenic for TA100, WP2 and WP2 uvrA− at concentrations up to about 1.0 μmole/plate when S9-mix was added to the test system and were toxic in the presence of a metabolic activation system for all strains tested.
Formaldehyde-induced sister chromatid exchanges in vitro and the influence of the exogenous metabolizing systems S9 mix and primary rat hepatocytes
The decrease in genotoxic effects, due to rapid metabolisation of formaldehyde in vitro and in vitro, explains the differences between results obtained in the in vitro experiments — performed without metabolizing systems — and in vivo results.
On the in-vitro mutagenicity of caramel colours
Commercial available caustic and ammoniated caramel colours were tested for their mutagenic potential using the Ames assay and none of the tested caramel colours showed any Mutagenic effect in the Ames test.
Studies on the genotoxicity of the anabolic drugs trenbolone and zeranol
Trenbolone did not demonstrate any genotoxic effect in the assays performed and the results obtained for zeranol were also negative in the SOS-chromotest and V79 sister chromatid exchange test but positive in the rec-assay.
In vitro SCE analysis of the veterinary anabolic drugs zeranol and trenbolone