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A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
TLDR
The cloning and characterization of GW2 is reported, a new QTL that controls rice grain width and weight and suggests that GW2 negatively regulates cell division by targeting its substrate(s) to proteasomes for regulated proteolysis. Expand
A dual thrombin receptor system for platelet activation
TLDR
It is reported that thrombin responses in platelets from PAR3-deficient mice were markedly delayed and diminished but not absent, and the identification of a two-receptor system for platelet activation byThrombin has important implications for the development of antithrombotic therapies. Expand
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
TLDR
This study not only advances the understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations. Expand
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
TLDR
A meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry followed up with de novo genotyping and further replication in east Asian samples provides new insights into blood pressure regulation and potential targets for intervention. Expand
Genetic evidence supports demic diffusion of Han culture
TLDR
It is shown, by systematically analysing Y-chromosome and mitochondrial DNA variation in Han populations, that the pattern of the southward expansion of Han culture is consistent with the demic diffusion model, and that males played a larger role than females in this expansion. Expand
Signaling and transcriptional regulation in osteoblast commitment and differentiation.
TLDR
This review summarizes the recent advances in the studies of signaling transduction pathways and transcriptional regulation of osteoblast cell lineage commitment and differentiation that enable a better understanding of the multiple factors and signaling networks that control the differentiation process at a molecular level. Expand
Forecasting stock market movement direction with support vector machine
TLDR
This paper investigates the predictability of financial movement direction with SVM by forecasting the weekly movement direction of NIKKEI 225 index and proposes a combining model by integrating SVM with the other classification methods. Expand
Enhanced Performance of Brain Tumor Classification via Tumor Region Augmentation and Partition
TLDR
The augmented tumor region via image dilation is used as the ROI instead of the original tumor region because tumor surrounding tissues can also offer important clues for tumor types. Expand
Role of thrombin signalling in platelets in haemostasis and thrombosis
TLDR
It is shown that platelets from PAR4-deficient mice failed to change shape, mobilize calcium, secrete ATP or aggregate in response to thrombin, and supports the model that mouse PAR3 (mPAR3) does not by itself mediate transmembrane signalling but instead acts as a cofactor forThrombin cleavage and activation of mPAR4. Expand
The genome sequences of Arachis duranensis and Arachis ipaensis, the diploid ancestors of cultivated peanut
TLDR
The genome sequences of its diploid ancestors are reported to show that these genomes are similar to cultivated peanut's A and B subgenomes and used to identify candidate disease resistance genes, to guide tetraploid transcript assemblies and to detect genetic exchange between cultivated peanuts' subgenome. Expand
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