• Publications
  • Influence
SNAREs and traffic.
  • W. Hong
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 30 June 2005
TLDR
This review aims to summarize the key properties and the mechanism of action of SNAREs in mammalian cells. Expand
Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform
TLDR
This study shows that membrane exchange between the early endocytic and the biosynthetic/secretory pathways involves specific components of the Rab and SNARE machinery, and suggests that retrograde transport between early/recycling endosomes and the endoplasmic reticulum is critically dependent on the sequential action of two members of therab6 subfamily. Expand
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.
TLDR
The results indicate that TAZ plays a role in the migration, invasion, and tumorigenesis of breast cancer cells and thus presents a novel target for the detection and treatment of Breast cancer. Expand
Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*
TLDR
Results reveal a novel mechanism to restrict the activity of TAZ and YAP through physical interaction with Amot and AmotL1, which was robustly co-immunoprecipitated with FLAG-tagged TAZ. Expand
Cidea-deficient mice have lean phenotype and are resistant to obesity
TLDR
It is shown that Cidea, a protein of unknown function sharing sequence similarity with the N-terminal region of DNA fragmentation factors Dffb and Dffa, is expressed at high levels in brown adipose tissue, and evidence that the role of CideA in regulating thermogenesis, lipolysis and obesity may be mediated in part through its direct suppression of Ucp1 activity is provided. Expand
The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*
TLDR
It is reported here that TAZ protein stability is controlled by a phosphodegron recognized by the F-box protein β-TrCP and ubiquitylated by the SCF/CRL1β-Tr CP E3 ligase. Expand
SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P
TLDR
It is shown that SNX3 is associated with the early endosome through a novel motif (PX domain) capable of interaction with phosphatidylinositol-3-phosphate (PtdIns(3)P). Expand
PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.
TLDR
It is demonstrated that Chinese hamster ovary cells stably expressing PRL-3, a M(r) 20000 prenylated protein tyrosine phosphatase, or its relative,PRL-1, exhibit enhanced motility and invasive activity, and it is shown that PRl-3 is associated with diverse membrane structures involved in cell movement. Expand
A Novel Severe Acute Respiratory Syndrome Coronavirus Protein, U274, Is Transported to the Cell Surface and Undergoes Endocytosis
TLDR
Coimmunoprecipitation experiments showed that U274 could interact specifically with the M, E, and S structural proteins, as well as with U122, another protein that is unique to SARS-CoV. Expand
GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.
TLDR
GLUT4 is rapidly transported from the cell surface to a subdomain of the trans-Golgi network that is enriched in the t-SNAREs Syntaxins 6 and 16 and that an acidic targeting motif in the C-terminal tail of GLUT4 plays an important role in this process. Expand
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