• Publications
  • Influence
SNAREs and traffic.
  • W. Hong
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 30 June 2005
SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are now generally accepted to be the major players in the final stage of the docking and the subsequent fusion ofExpand
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Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform
The molecular mechanisms underlying early/recycling endosomes-to-TGN transport are still not understood. We identified interactions between the TGN-localized putative t-SNAREs syntaxin 6, syntaxinExpand
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A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.
TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role in the migration, invasion,Expand
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Cidea-deficient mice have lean phenotype and are resistant to obesity
The thermogenic activity of brown adipose tissue (BAT), important for adaptive thermogenesis and energy expenditure, is mediated by the mitochondrial uncoupling protein1 (Ucp1) that uncouples ATPExpand
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The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ cytoplasmicExpand
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Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In this report, we describe an independentExpand
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SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P
The sorting nexin (SNX) protein family is implicated in regulating membrane traffic, but the mechanism is still unknown. We show that SNX3 is associated with the early endosome through a novel motifExpand
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PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.
  • Qi Zeng, J. Dong, +6 authors W. Hong
  • Biology, Medicine
  • Cancer research
  • 1 June 2003
We demonstrate here that Chinese hamster ovary cells stably expressing PRL-3, a M(r) 20000 prenylated protein tyrosine phosphatase, or its relative, PRL-1, exhibit enhanced motility and invasiveExpand
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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome
Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and trafficking. Here we show that Snx27−/− mice have severe neuronal deficits in the hippocampus andExpand
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A Novel Severe Acute Respiratory Syndrome Coronavirus Protein, U274, Is Transported to the Cell Surface and Undergoes Endocytosis
ABSTRACT The severe acute respiratory syndrome coronavirus (SARS-CoV) genome contains open reading frames (ORFs) that encode for several genes that are homologous to proteins found in all knownExpand
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