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Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update
This paper follows the same procedures described previously to develop an updated list of SDRMs that are likely to be useful for ongoing and future studies of transmitted drug resistance and concludes that the updated SDRM list has 93 mutations.
Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters
- N. Wolfe, W. Heneine, W. Switzer
- Biology, MedicineProceedings of the National Academy of Sciences…
- 23 May 2005
The findings indicate that cross-species transmission is not the rate-limiting step in pandemic retrovirus emergence and suggest that it may be possible to predict and prevent disease emergence by surveillance of populations exposed to animal reservoirs and interventions to decrease risk factors, such as primate hunting.
Naturally acquired simian retrovirus infections in central African hunters
Susceptibility of HIV-2, Siv and Shiv to Various Anti-HIV-1 Compounds: Implications for Treatment and Postexposure Prophylaxis
- M. Witvrouw, C. Pannecouque, W. Switzer, T. Folks, E. Clercq, W. Heneine
- Biology, MedicineAntiviral therapy
- 1 January 2004
Findings support the use of NRTIs, tenofovir, but not NN RTIs, for treating HIV-2-infected persons or for prophylaxis against HIV- 2 and SIV, and show co-receptor antagonists such as AMD3100 show promising anti-HIV-2 therapeutic modalities.
Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis
- D. Kuhar, D. Henderson, A. Panlilio
- MedicineInfection Control & Hospital Epidemiology
- 5 August 2013
To ensure timely postexposure management and administration of HIV PEP, clinicians should consider occupational exposures as urgent medical concerns, and institutions should take steps to ensure that staff are aware of both the importance of and the institutional mechanisms available for reporting and seeking care for such exposures.
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.
Minority HIV-1 Drug Resistance Mutations Are Present in Antiretroviral Treatment–Naïve Populations and Associate with Reduced Treatment Efficacy
It is found that a considerable proportion of transmitted HIV-1 drug resistance is undetected by conventional genotyping and that minority mutations can have clinical consequences, suggesting an important role for sensitive baseline drug resistance testing.
Prevalence of transmitted drug resistance associated mutations and HIV-1 subtypes in new HIV-1 diagnoses, U.S.–2006
The prevalence of TDRM in persons newly diagnosed with HIV is higher than in previous U.S. studies; however, this is not necessarily a significant trend and continued reporting of sequence data from all sources will improve representativeness and accuracy in analyzing trends in transmitted drug resistance and genetic diversity.
Multiple Groups of Novel Retroviral Genomes in Pigs and Related Species
Analysis of DNA from wild boar and other species of Old World pigs and New World peccaries showed that one retrovirus group was common to all species tested, while the others were present among all Old World species but absent from New World species.
The epidemiology of antiretroviral drug resistance among drug-naive HIV-1-infected persons in 10 US cities.
Depending on the characteristics of the patients tested, HIV-genotype testing prior to the initiation of therapy would identify a substantial number of infected persons with mutations associated with reduced antiretroviral-drug susceptibility.