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- Publications
- Influence
Asymmetric hydrogenation of isobutyrophenone using a [(Diphosphine) RuCl2 (1,4-diamine)] catalyst.
- G. Grasa, A. Zanotti-Gerosa, J. Medlock, W. Hems
- Chemistry, Medicine
- Organic letters
- 15 March 2005
[reaction: see text] The use of three chiral 1,4-diamines in the [(diphosphine) RuCl(2) (diamine)] catalyst system is demonstrated in the hydrogenation of acetophenone. The use of a 1,4-diamine… Expand
Synthesis of Highly Cross-Linked Polymers in Supercritical Carbon Dioxide by Heterogeneous Polymerization
- A. Cooper, W. Hems, A. B. Holmes
- Chemistry
- 10 March 1999
This paper reports the synthesis of highly cross-linked polymers in supercritical CO2 (scCO2), both with and without the addition of a CO2-soluble diblock copolymer stabilizer. It was demonstrated… Expand
Asymmetric hydrogenation using chiral Rh complexes immobilised with a new ion-exchange strategy.
- W. Hems, P. McMorn, Stewart Riddel, S. Watson, Frederich E Hancock, G. Hutchings
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 12 April 2005
Rh diphosphine complexes using DuPhos and JosiPhos as chiral ligands have been immobilised by ion exchange into the mesoporous material MCM-41. When used as catalysts for the enantioselective… Expand
Studies on the preparation of camphorylidene derivatives of α-amino acids
- David L. Gamble, W. Hems, B. Ridge
- Chemistry
- 2001
An improved method has been developed for the efficient synthesis of stable camphor imine salts. Camphor imine readily undergoes transimination with α-amino acid ester hydrochlorides to yield… Expand
Accelerated asymmetric transfer hydrogenation of aromatic ketones in water.
- Xiaofeng Wu, X. Li, W. Hems, F. King, J. Xiao
- Medicine, Chemistry
- Organic & biomolecular chemistry
- 28 June 2004
Asymmetric transfer hydrogenation of various simple aromatic ketones by the Ru-TsDPEN catalyst was shown to be feasible in aqueous HCOONa without calling for any catalyst modification, furnishing… Expand
A Catalyst for Efficient and Highly Enantioselective Hydrogenation of Aromatic, Heteroaromatic, and α,β-Unsaturated Ketones
- M. Burk, W. Hems, D. Herzberg, C. Malan, A. Zanotti-Gerosa
- Chemistry
- 1 December 2000
PhanePhos−ruthenium−diamine complexes catalyze the asymmetric hydrogenation of a wide range of aromatic, heteroaromatic, and α,β-unsaturated ketones with high activity and excellent… Expand
[(Bisphosphine) Ru(II) diamine] complexes in asymmetric hydrogenation: expanding the scope of the diamine ligand.
- W. Hems, M. Groarke, Antonio Zanotti-Gerosa, G. Grasa
- Chemistry, Medicine
- Accounts of chemical research
- 19 June 2007
[(Bisphosphine) RuCl 2 (1,2-diamine)] complexes are powerful catalysts in the asymmetric hydrogenation of unfunctionalized ketones. We sought to expand the scope and applicability of these complexes… Expand
Carbohydrate-derived amino-alcohol ligands for asymmetric alkynylation of aldehydes.
- Daniel P. G. Emmerson, W. Hems, B. Davis
- Chemistry, Medicine
- Organic letters
- 19 January 2006
[reaction: see text] Conformationally restricted amino alcohols based on carbohydrate scaffolds provide flexible and fine-tuneable libraries that greatly expand the range of ligands available in the… Expand
Practical Asymmetric Synthesis of (+)-erythro Mefloquine Hydrochloride
- W. Hems, W. P. Jackson, P. Nightingale, R. Bryant
- Chemistry
- 6 March 2012
A highly enantioselective and cost efficient process for the synthesis of (+)-erythro mefloquine has been developed. The key step is an enantioselective reduction of pyridyl ketone KI using transfer… Expand
Ruthenium-Catalysed Asymmetric Reduction of Ketones
- Antonio Zanotti-Gerosa, W. Hems, M. Groarke, F. Hancock
- Chemistry
- 1 October 2005
ketones is a reaction of particular importance to the pharmaceutical industry. In the 1980s, research by Professor Ryoji Noyori’s group at Nagoya University in Japan, on BINAP-ruthenium catalysts… Expand