Aberrant CpG-island methylation has non-random and tumour-type–specific patterns
- J. Costello, M. Frühwald, C. Plass
- BiologyNature Genetics
- 1 February 2000
This report reports a global analysis of the methylation status of 1,184 unselected CpG islands in each of 98 primary human tumours using restriction landmark genomic scanning (RLGS), and estimates that an average of 600 C pG islands were aberrantly methylated in the tumours, including early stage tumours.
Assembly mapping of 30 S ribosomal proteins from Escherichia coli. Further studies.
- W. Held, B. Ballou, S. Mizushima, M. Nomura
- BiologyJournal of Biological Chemistry
- 25 May 1974
Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS–M
- C. Plass, H. Shibata, V. Chapman
- BiologyNature Genetics
- 1 September 1996
The characterisation of a novel imprinted RLGS-M locus, Irlgs3, on mouse chromosome 9 is described, which indicates that imprinting may have a role in regulating mitogenic signal transduction pathways during growth and development.
Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression.
- Fei Song, Joseph F Smith, W. Held
- BiologyProceedings of the National Academy of Sciences…
- 1 March 2005
Analysis of 14 TDMs by methylation-specific PCR and by bisulfite genomic sequencing confirms that the regions identified by RLGS are differentially methylated in a tissue-specific manner, disputing the general notion that all CpG islands are unmethylated.
Reconstitution of Escherichia coli 30 S ribosomal subunits from purified molecular components.
- W. Held, S. Mizushima, M. Nomura
- BiologyJournal of Biological Chemistry
- 25 August 1973
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies.
- D. Smiraglia, L. Rush, C. Plass
- BiologyHuman Molecular Genetics
- 15 June 2001
Data indicate that most CpG island hypermethylation observed in cancer cell lines is due to an intrinsic property of cell lines as opposed to the malignant tissue from which they originated.
Differential, Multihormonal Regulation of the Mouse Major Urinary Protein Gene Family in the Liver
- J. Knopf, J. Gallagher, W. Held
- Biology, MedicineMolecular and Cellular Biology
- 1 December 1983
Evidence is presented which indicates that growth hormone, thyroxine, and testosterone differentially regulate the levels of distinct MUP mRNA species.
Subfamilies of the mouse major urinary protein (MUP) multi-gene family: sequence analysis of cDNA clones and differential regulation in the liver.
- N. J. Kuhn, M. Woodworth-Gutai, K. Gross, W. Held
- BiologyNucleic Acids Research
- 10 August 1984
Southern blot analysis of mouse genomic DNA indicates that there are multiple genes homologous to each sequence, and analysis of liver RNA from mice in different endocrine states indicates that the p499-5' sequence is strongly regulated by thyroxine administration whereas the p199-5', appears to be regulated by growth hormone and testosterone.
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