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Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
Somatic hypermutation of light chain V genes during development of B cells in sheep ileal Peyer's patches was studied in three experimental conditions: in sterile fragments of the ileum surgicallyExpand
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Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration
The lymphatic absorption of four water-soluble compounds with different molecular weights (MW) was determined by measuring their cumulative recovery in lymph draining from the site of s.c.Expand
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Prominence of γδ T cells in the ruminant immune system
Abstract The lymphoid systems of sheep and cattle contain a large number of γδ T cells, in striking contrast to the lymphoid systems of humans and mice. In neonatal animals particularly, these cellsExpand
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Prominence of gamma delta T cells in the ruminant immune system.
The lymphoid systems of sheep and cattle contain a large number of gamma delta T cells, in striking contrast to the lymphoid systems of humans and mice. In neonatal animals particularly, these cellsExpand
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Divergent evolution of T cell repertoires: extensive diversity and developmentally regulated expression of the sheep gamma delta T cell receptor.
Sheep gamma delta T cells express an unprecedented repertoire of antigen receptors contributed by increased diversity in both variable and constant region gene segments. Variable region diversityExpand
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Expanding the role of Peyer's patches in B-cell ontogeny.
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A large proportion of bovine T cells express the γδ T cell receptor and show a distinct tissue distribution and surface phenotype
: The numbers, phenotype, and tissue distribution of gamma delta T cells in cattle were studied using two monoclonal antibodies (mAbs) which react with the bovine gamma delta T cell receptor (TCR).Expand
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Increased Expression of Interleukin-5 (IL-5), IL-13, and Tumor Necrosis Factor Alpha Genes in Intestinal Lymph Cells of Sheep Selected for Enhanced Resistance to Nematodes during Infection with
ABSTRACT Cytokine gene expression in cells migrating in afferent and efferent intestinal lymph was monitored for extended time periods in individual sheep experimentally infected with the nematodeExpand
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Tissue‐specific migration pathways by phenotypically distinct subpopulations of memory T cells
A proportion of T cells recirculate in a tissue‐selective manner. Recent studies which showed that the skin‐tropic subset of T cells was of memory/activated type, led us to examine whether theExpand
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Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis.
Allergens were identified from the gastrointestinal nematode of sheep, Trichostrongylus colubriformis, by probing Western blots of infective larvae (third stage) somatic antigen with IgE purifiedExpand
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