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  • W. Hausdorff, M. Bouvier, B. O'dowd, G. P. Irons, M. Caron, R. Lefkowitz
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1989 (First Publication: 25 July 1989)
  • Continuous exposure of cells to neurotransmitter or hormone agonists often results in a rapid desensitization of the cellular response. For example, pretreatment of Chinese hamster fibroblasts (CHWExpand
  • Stephen B. Liggett, Marlène Bouvier, William P. Hausdorff, Brian F O'dowd, Marc G. Caron, Robert J Lefkowitz
  • Biology, Medicine
  • Molecular pharmacology
  • 1989 (First Publication: 1 October 1989)
  • As with many other receptor-effector systems, the responsiveness of the beta-adrenergic receptor (beta AR)/adenylyl cyclase system undergoes desensitization upon agonist exposure. Phosphorylations ofExpand
  • William P. Hausdorff, Martin J. Lohse, Michel Bouvier, Stephen B. Liggett, Marc G. Caron, Robert J Lefkowitz
  • Chemistry, Medicine
  • Symposia of the Society for Experimental Biology
  • 1990
  • Binding of the catecholamine agonists epinephrine and norepinephrine to the beta-adrenergic receptor (BAR) rapidly activates adenylate cyclase via the stimulatory guanine nucleotide regulatoryExpand