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Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11.
TLDR
The presence of not one but three spermatogenesis loci in Yq11 is proposed and that each locus is active during a different phase of male germ cell development. Expand
Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria.
TLDR
It is indicated that the subpopulation of MTS patients who are also affected by colorectal cancer, irrespective of family history and age at onset of tumors, may have a likelihood for an underlying DNA MMR defect similar to that for patients with a family history fulfilling the strict clinical criteria for HNPCC. Expand
Ultrastructural connective tissue abnormalities in patients with spontaneous cervicocerebral artery dissections
TLDR
Observations indicate a correlation of cervical artery dissections with connective tissue abnormalities and a structural abnormality in the extracellular matrix potentially caused by basic molecular defects is suggested and warrants further exploration. Expand
High-grade trichoblastic carcinoma arising in trichoblastoma: a rare adnexal neoplasm often showing metastatic spread.
TLDR
It is emphasized that high-grade trichoblastic carcinoma develops via malignant transformation of trichoblastoma, and is very rare. Expand
Presence and coexistence of chromogranin A and multiple neuropeptides in Merkel cells of mammalian oral mucosa
TLDR
The results indicate that the chemical coding of Merkel cells in mammalian oral mucosa is much more complex than previously described and depends on the developmental stage. Expand
Coexpression of cholinergic and noradrenergic phenotypes in human and nonhuman autonomic nervous system
TLDR
A mode of autonomic regulation, based on corelease of norepinephrine and acetylcholine at parasympathocardiac, sudomotor, and selected vasomotor neuroeffector junctions, that is unique to the primate peripheral nervous system is suggested. Expand
Merkel cells are absent in basal cell carcinomas but frequently found in trichoblastomas. An immunohistochemical study
TLDR
The present immunohistochemical study, applying the cytokeratins 8, 18 and 20 as the most established markers for Merkel cells (MCs), did not find elevated numbers of MCs in any of 205 BCCs, which speaks against a neuroendocrine line of differentiation in BCCs. Expand
Cytokeratins as Markers of Follicular Differentiation: An Immunohistochemical Study of Trichoblastoma and Basal Cell Carcinoma
TLDR
Trichoblastoma(s) and BCC show consistent expression of CK6hf, CK14, and CK17; variableexpression of CK15 and CK19; and absence of hair keratins, which indicates a differentiation toward the outer root sheath epithelium or the companion layer and not toward the innerroot sheath, matrix, or cortex. Expand
Classifying ambiguous melanocytic lesions with FISH and correlation with clinical long-term follow up
TLDR
The FISH technique with its present composition of locus-specific probes for RREB1/MYB and CCND1 did not achieve a clinically useful sensitivity and specificity, and a reassessment of the probes and better standardization of the method may lead to a valuable diagnostic tool. Expand
Localization of Xenin-immunoreactive Cells in the Duodenal Mucosa of Humans and Various Mammals
TLDR
Immunocytochemical expression of the peptide xenin in a subpopulation of chromogranin A-positive cells as well as the localization of xenin immunoreactivity in ultrastructurally characterized secretory granules permitted the identification of a novel endocrine cell type as the cellular source of circulating xenin. Expand
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