W. Harris

Publications159
h-index26
Citations2,460
Highly Influential Citations66
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The Herpes Simplex Virus Type 1 UL17 Gene Encodes Virion Tegument Proteins That Are Required for Cleavage and Packaging of Viral DNA
ABSTRACT Previous studies have suggested that the UL17 gene of herpes simplex virus type 1 (HSV-1) is essential for virus replication. In this study, viral mutants incorporating either a… Expand
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Ovarian gonadotrophin surge-attenuating factor (GnSAF): where are we after 20 years of research?
When gonadotrophin-stimulated IVF methods were being developed in the 1970s and 1980s, understanding of the physiology of FSH improved. In addition to its classic actions of stimulating aromatase… Expand
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Static fatigue of granite at 200°C
Cylinders of Barre and Westerly granites have been compressed to failure in static fatigue tests under dry and wet conditions at 1 Kb confining pressure and temperatures of 24/sup 0/ and 200 /sup… Expand
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Humanized antibodies.
Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering is now generating antibodies for… Expand
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Escherichia coli skp chaperone coexpression improves solubility and phage display of single-chain antibody fragments.
Expression of single-chain antibody fragments (scAb)in the periplasm of Escherichia coli often results in low soluble product yield and cell lysis. We have increased scAb solubility and prevented… Expand
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Specificity analysis of blood group Lewis-y (Le(y)) antibodies generatedagainst synthetic and natural Le(y) determinants.
Le(y)-reactive monoclonal antibodies (mAbs) were generated in mice by immunization with synthetic Le(y) neoglycoproteins or with Le(y)-expressing cells. Serological analysis indicated that mAbs… Expand
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Construction, production, and characterization of humanized anti-Lewis Y monoclonal antibody 3S193 for targeted immunotherapy of solid tumors.
The Lewis Y (Ley) antigen is a blood group-related antigen that is expressed in a high proportion of epithelial cancers (including breast, colon, ovary, and lung cancer) and is an attractive target… Expand
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STUDIES ON THE STRUCTURE OF VACCINIA VIRUS.
SUMMARY: Vaccinia virus has been examined with the electron microscope by several techniques in conjunction with experimental modifications of structure. Negative staining revealed that over 80% of… Expand
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The isolation of super-sensitive anti-hapten antibodies from combinatorial antibody libraries derived from sheep.
The complexity and expense of producing anti-hapten monoclonals via the traditional hybridoma route and the preferential selection of antibodies that recognise the conjugated form of the hapten, over… Expand
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Repair of 4-nitroquinoline-1-oxide-induced DNA damage in normal human cells and cells from classical and variant xeroderma pigmentosum.
The effect of 4-nitroquinoline-1-oxide (4NQO) upon 3 fibroblast cell lines derived from normal and xeroderma pigmentosum subjects have been compared. Excision-deficient XP cells (XP2BI),… Expand
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