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- Publications
- Influence
125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT: a selective oxytocin receptor ligand.
- J. Elands, C. Barberis, +5 authors W. H. Sawyer
- Biology, Medicine
- European journal of pharmacology
- 1 March 1988
An oxytocic antagonist, [1-(beta-mercapto-beta, beta-cyclopentamethylenepropionic acid,2-O-methyltyrosine,4-threonine, 8-ornithine,9-tyrosylamide]vasotocin (d(CH2)5[Tyr(Me)2, Thr4,Tyr-NH2(9)]OVT… Expand
[1-beta-Mercapto-beta,beta-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine ]argine-vasopressin and [1-beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)]argine-vasopressine, two…
- M. Kruszynski, B. Lammek, M. Manning, J. Seto, J. Haldar, W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 April 1980
Vasopressin antagonists allow demonstration of a novel type of vasopressin receptor in the rat adenohypophysis.
- S. Jard, R. Gaillard, +5 authors W. H. Sawyer
- Biology, Medicine
- Molecular pharmacology
- 1 August 1986
The ligand specificity of rat adenohypophyseal vasopressin receptors was directly compared to that of peripheral receptors of the V1 and V2 types. For this purpose a series of 15 recently designed… Expand
Discovery, development, and some uses of vasopressin and oxytocin antagonists.
- M. Manning, W. H. Sawyer
- Biology, Medicine
- The Journal of laboratory and clinical medicine
- 1 December 1989
The past decade has witnessed an astonishing resurgence of interest in the neurohypophysial peptides oxytacin and vasopressin. The availability of antagonists for vasopressin and oxytocin has been a… Expand
Renal adaptations by Opsanus tau, a euryhaline aglomerular teleost, to dilute media.
- B. Lahlou, I. Henderson, W. H. Sawyer
- Chemistry, Medicine
- The American journal of physiology
- 1 May 1969
Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin.
- M. Manning, M. Kruszynski, +7 authors W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 February 1989
We describe the synthesis and some pharmacological properties of 16 new in vivo antagonists of oxytocin. These are based on modifications of three peptides: A, B, and C. A is our previously reported… Expand
Neural Influences on Bullfrog Renal Functions
- R. Gallardo, P. Pang, W. H. Sawyer
- Medicine
- Proceedings of the Society for Experimental…
- 1 November 1980
Abstract The present investigations suggest that α-adrenergic mechanisms may be involved in the control of glomerular and tubular functions of bullfrog kidneys. Hypothalamic lesions did not… Expand
AVIAN NEUROHYPOPHYSIAL HORMONES: PHARMACOLOGICAL PROPERTIES AND TENTATIVE IDENTIFICATION
- R. A. Munsick, W. H. Sawyer, H. B. Dyke
- Biology
- 1 June 1960
The pattern of pharmacological activities in the chicken ncurohypophysis has been studied and described. These activities correspond to those of a mixture of oxytocin and arginine vasotocin, an… Expand
Synthesis and some pharmacological properties of potent and selective antagonists of the vasopressor (V1-receptor) response to arginine-vasopressin.
- M. Manning, S. Stoev, +4 authors W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 24 January 1992
We report the solid-phase synthesis of eight position-9-modified analogues of the potent V1-receptor antagonist of arginine-vasopressin, [1-(beta-mercapto-beta,beta-pentamethylenepropionic… Expand