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Teratogenicity of phthalate esters in rats.
In the past, it was demonstrated that small quantities of phthalates may be released from polyvinyl chloride items to physiological solutions. To ascertain the effect these plasticizers might haveExpand
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Injected apomorphine and orally administered levodopa in Parkinsonism.
Among 31 patients with parkinsonism three investigations were performed by injecting apomorphine hydrochloride or placebo: (1) to 17 patients with or without orally administered levodopa, (2) to 14Expand
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Mutagenicity evaluation of phthalic acid esters and metabolites in Salmonella typhimurium cultures.
The mutagenic potential of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), and di-2-ethylhexyl phthalate (DEPH), as well as metabolites of DEHP--i.e., mono-2-ethylhexylExpand
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Maternal-fetal transfer of 14C-di-2-ethylhexyl phthalate and 14C-diethyl phthalate in rats.
14C-Di-2-ethylhexyl and 14C-diethyl phthalates were administered intraperitoneally to pregnant rats on either Day 5 or 10 of gestation. Rats were sacrificed at 24-hr intervals starting on Days 8 andExpand
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Use of Mathematical Models in the Study of Structure-Toxicity Relationships of Dental Compounds: I. Esters of Acrylic and Methacrylic Acids
The toxicity of a series of esters of acrylic and methacrylic acids was determined in groups of mice, and the resultant LD50 values were analyzed with the use of the mathematical models of Free andExpand
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Embryonic-fetal toxicity and teratogenic effects of adipic acid esters in rats.
Abstract Seven adipates (dimethyl, diethyl, dipropyl, diisobutyl, di-n-butyl, di-2-ethylhexyl, and dicyclohexyl) were evaluated for their embryonic-fetal toxicity and teratogenic effects in rats, andExpand
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Subacute toxicity testing of biomaterials using histopathologic evaluation of rabbit muscle tissue.
A group of 12 materials was evaluated for tissue compatibility via a sequential histopathologic evaluation of the rabit muscle response to the implanted materials. Tissue samples were obtained dailyExpand
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A toxicological investigation of some acute, short-term, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters.
Twelve phthalic acid esters, including those commonly used as plasticizers for biomedical devices, were subjected to various biological tests for acute, short-term, and chronic toxicity. CertainExpand
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Embryonic-Fetal Toxicity and Teratogenic Effects of a Group of Methacrylate Esters in Rats
Monomers of five methacrylate esters and acrylic acid were administered at three dose levels to female rats on days 5, 10, and 15 of gestation. The incidences of resorptions, dead fetuses, grossExpand
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Hypergastrinemia in obese noninsulin-dependent diabetes: a possible reflection of high prevalence of vagal dysfunction.
To elucidate the relation of noninsulin-dependent (type II) diabetes mellitus to plasma levels of gastrin, pepsinogen I, and pepsinogen II, gastric acid secretion, and gastric emptying, we studiedExpand
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