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The TSC-mTOR signaling pathway regulates the innate inflammatory response.
The innate inflammatory immune response must be tightly controlled to avoid damage to the host. Here, we showed that the tuberous sclerosis complex-mammalian target of rapamycin (TSC-mTOR) pathwayExpand
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Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure.
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A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation
The mammalian target of rapamycin (mTOR) regulates cell growth and survival and exists as rapamycin-sensitive mTOR complex (mTORC) 1 and as rapamycin-insensitive mTORC2. Although mTOR is a well-knownExpand
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Anti‐inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL‐12 and up‐regulation of IL‐10 production
Cytokines are critical in regulating unresponsiveness versus immunity towards enteric antigens derived from the intestinal flora and ingested food. There is increasing evidence that butyrate, a majorExpand
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Kidney Disease: Improving Global Outcomes guidelines on anaemia management in chronic kidney disease: a European Renal Best Practice position statement.
Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) group has produced comprehensive clinical practice guidelines for the management of anaemia in CKD patients. These guidelines addressedExpand
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Effect of age on human neutrophil function
Neutrophil phagocytosis, reactive oxygen intermediate production (intra‐ and extracellular), neutrophil bactericidal activity, and chemotaxis/chemokinesis were assessed in three age groups: 21–36,Expand
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Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection.
BACKGROUND Capillary deposition of complement split product C4d has been suggested to be a valuable marker for humoral rejection. In this retrospective study we evaluated the clinical impact of C4dExpand
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Nutritional status in dialysis patients: a European consensus.
BACKGROUND Malnutrition is common in dialysis patients and closely related to morbidity and mortality. Therefore, assessment of nutritional status and nutritional management of dialysis patients playExpand
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Molecular biology of 5,10-methylenetetrahydrofolate reductase.
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the amino acid homocysteine. It catalyzes the reduction ofExpand
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Serum amyloid A in uremic HDL promotes inflammation.
Uremia impairs the atheroprotective properties of HDL, but the mechanisms underlying why this occurs are unknown. Here, we observed that HDL isolated from healthy individuals inhibited the productionExpand
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