W. Guo

Publications483
h-index43
Citations7,976
Highly Influential Citations403
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Structure of the PIN/LC8 dimer with a bound peptide
The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray… Expand
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Robustness of Cortical Topography across Fields, Laminae, Anesthetic States, and Neurophysiological Signal Types
Topographically organized maps of the sensory receptor epithelia are regarded as cornerstones of cortical organization as well as valuable readouts of diverse biological processes ranging from… Expand
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Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
Cancer stem cells, which share many common properties and regulatory machineries with normal stem cells, have recently been proposed to be responsible for tumorigenesis and to contribute to cancer… Expand
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The PI3K/AKT Pathway and Renal Cell Carcinoma.
The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway, and thus is frequently… Expand
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JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription
Signal transducer and activator of transcription 3 (STAT3) was reported to be involved in adipogenesis. However, the regulating mechanism of STAT3 remains unclear. The present results showed that… Expand
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Identification of miRs-143 and -145 that Is Associated with Bone Metastasis of Prostate Cancer and Involved in the Regulation of EMT
The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to bone. MicroRNAs (miRNAs) play a crucial role in many tumor metastases. The importance of miRNAs in bone… Expand
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MicroRNA‐9 up‐regulates E‐cadherin through inhibition of NF‐κB1–Snail1 pathway in melanoma
MicroRNAs (miRNAs) are short non‐coding RNAs that post‐transcriptionally regulate gene expression. Hsa‐miR‐9 has been shown to have opposite functions in different tumour types; however, the… Expand
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microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells.
PE (pre-eclampsia), a pregnancy-specific disorder, is characterized by increased trophoblast cell death and deficient trophoblast invasion and reduced trophoblast-mediated remodelling of spiral… Expand
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Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
The constant self renewal and differentiation of adult intestinal stem cells maintains a functional intestinal mucosa for a lifetime. However, the molecular mechanisms that regulate intestinal stem… Expand
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Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China
As an important long noncoding RNA, Hox transcript antisense intergenic RNA (HOTAIR) is involved in the development and progression of various carcinomas. However, the role and genetic alterations of… Expand
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