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Wall stress and patterns of hypertrophy in the human left ventricle.
TLDR
The hypothesis that hypertrophy develops to normalize systolic but not diastolic wall stress is suggested, and it is proposed that increased syStolic tension development by myocardial fibers results in fiber thickening just sufficient to return the systolics stress (force per unit cross-sectional area) to normal. Expand
Survival After the Onset of Congestive Heart Failure in Framingham Heart Study Subjects
TLDR
Advances in the treatment of hypertension, myocardial ischemia, and valvular heart disease during the four decades of observation did not translate into appreciable improvements in overall survival after the onset of CHF in this large, unselected population. Expand
Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.
TLDR
These experiments provide the first direct evidence from actively contracting human myocardium that intracellular Ca2+ handling is abnormal and may cause systolic and diastolic dysfunction in heart failure. Expand
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.
TLDR
An abnormality in cyclic AMP production may be a fundamental defect present in patients with end-stage heart failure that can markedly diminish the effectiveness of agents that depend on generation of this nucleotide for production of a positive inotropic effect. Expand
Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches.
TLDR
It is concluded that both area- and length- based measurements can be used to determine relative infarct size over a wide range of severity, although the area-based measurements are substantially more compressed due to wall thinning, and that the estimation ofinfarct midlines is a simple, reliable approach to infarCT size assessment. Expand
Left Ventricular Systolic Unloading and Augmentation of Intracoronary Pressure and Doppler Flow During Enhanced External Counterpulsation
TLDR
The combined effects of systolic unloading and increased coronary perfusion pressure provide evidence that EECP may serve as a potential mechanical assist device. Expand
Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension.
TLDR
Levels of circulating endothelial PECAM(+) and VE-cadherin(+), E-selectin (+), and leukocyte-derived MPs, but not platelet and annexin V(+) MPs, were increased in subjects with PH compared with control subjects and predicted hemodynamic severity of the disease. Expand
First-pass nuclear magnetic resonance imaging studies using gadolinium-DTPA in patients with coronary artery disease.
TLDR
The results demonstrate the clinical potential of dynamic gadolinium-DTPA-enhanced NMR imaging for the assessment of coronary artery disease in patients with chest pain and has the potential to provide a comprehensive noninvasive cardiac evaluation of patients with suspected coronary arteries disease. Expand
Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production.
TLDR
Brief exposure to real-world levels of SHS leads to sustained vascular injury characterized by mobilization of dysfunctional EPCs with blocked nitric oxide production, suggesting endothelial activation and injury with functional impairment of the vascular endothelium. Expand
Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease.
TLDR
Improvements in endothelial dysfunction by regular dietary intake of flavanols are associated with mobilization of functional CACs, and a mixed-effects linear regression model demonstrated a significant increase in flow-mediated vasodilation and a decrease in systolic blood pressure with increasing levels of CD34+/KDR+-CACs. Expand
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