• Publications
  • Influence
Chemopreventive agents: selenium.
  • G. Combs, W. Gray
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 1 October 1998
The element selenium (Se) was recognized only 40 years ago as being essential in the nutrition of animals and humans. It is recognized as being an essential component of a number of enzymes, in whichExpand
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Neuropeptide Y stimulates neuronal precursor proliferation in the post‐natal and adult dentate gyrus
Adult dentate neurogenesis is important for certain types of hippocampal‐dependent learning and also appears to be important for the maintenance of normal mood and the behavioural effects ofExpand
  • 176
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Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat
Granule cell progenitors in the dentate gyrus of the hippocampal formation have the unusual capacity to be able to divide in the brains of adult rats and primates. The basal proliferation rate ofExpand
  • 342
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Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
Early embryonic development is known to be susceptible to maternal undernutrition, leading to a disease‐related postnatal phenotype. To determine whether this sensitivity extended into oocyteExpand
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Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus
We have shown that neuropeptide Y (NPY) regulates neurogenesis in the normal dentate gyrus (DG) via Y(1) receptors (Howell, O.W., Scharfman, H.E., Herzog, H., Sundstrom, L.E., Beck-Sickinger, A. andExpand
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Neuropeptide Y is neuroproliferative for post‐natal hippocampal precursor cells
New neurones are produced in the adult hippocampus throughout life and are necessary for certain types of hippocampal learning. Little, however, is known about the control of hippocampalExpand
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Seizures preferentially stimulate proliferation of radial glia‐like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis
Kainate‐induced seizures increase hippocampal neurogenesis. Glial fibrillary acidic protein‐positive astrocytes with radial processes in the dentate gyrus share many of the characteristics of radialExpand
  • 171
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Relevance of Seizure‐Induced Neurogenesis in Animal Models of Epilepsy to the Etiology of Temporal Lobe Epilepsy
Summary:  Seizure induction in laboratory animals is followed by many changes in structure and function, and one of these is an increase in neurogenesis—the birth of new neurons. This phenomenon mayExpand
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Opportunities for improving animal welfare in rodent models of epilepsy and seizures
Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers,Expand
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