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Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. AsExpand
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New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affectingExpand
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Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, butExpand
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Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
Recent integrative genomic approaches have defined molecular subgroups of medulloblastoma that are genetically and clinically distinct. Sonic hedgehog (Shh) medulloblastomas account for one-third ofExpand
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Congenital subependymal giant cell astrocytomas in patients with tuberous sclerosis complex
PurposeSubependymal giant cell astrocytoma (SEGA) is a brain tumor associated with tuberous sclerosis complex (TSC). It usually grows in a second decade of life, but may develop in the first monthsExpand
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Altered MicroRNA Expression Is Associated with Tumor Grade, Molecular Background and Outcome in Childhood Infratentorial Ependymoma
Background Ependymal tumors are the third most common group of brain tumors in children, accounting for about 10% of all primary brain neoplasms. According to the current WHO classification, theyExpand
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Surgical treatment of subependymal giant cell astrocytoma in tuberous sclerosis complex patients.
BACKGROUND Subependymal giant cell astrocytoma is a brain tumor associated with tuberous sclerosis complex. There are two treatment options for subependymal giant cell astrocytomas: surgery orExpand
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Papillary pineocytoma in child: a case report.
BACKGROUND Papillary pineocytoma is an extremely rare tumor usually with a poor outcome. CASE REPORT We report a case of a 10-year-old-girl with pineal gland tumor and obstructive hydrocephalusExpand
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Tuberin and Hamartin Expression Is Reduced in the Majority of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex Consistent With a Two-Hit Model of Pathogenesis
Subependymal giant cell astrocytomas are distinctive brain tumors that are seen only in tuberous sclerosis complex. Although histologically benign, they cause both moribidity and occasional mortalityExpand
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Significance of low desmin expression in cardiomyocytes in patients with idiopathic dilated cardiomyopathy.
Desmin plays an essential role in maintaining cell cytoarchitecture, positioning and functioning of organelles, and the intercellular signaling pathway. It has been suggested that remodeling ofExpand
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