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Basic local alignment search tool.
- S. Altschul, W. Gish, Webb Miller, E. Myers, D. Lipman
- Medicine, Biology
- Journal of molecular biology
- 1 October 1990
A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP)… Expand
Initial sequencing and analysis of the human genome.
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and… Expand
Basic local alignment search tool. Journal of Molecular Biology
Identification of protein coding regions by database similarity search
Sequence similarity between a translated nucleotide sequence and a known biological protein can provide strong evidence for the presence of a homologous coding region, even between distantly related… Expand
Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map
Single nucleotide polymorphisms (SNPs) are valuable genetic markers of human disease. They also comprise the highest potential density marker set available for mapping experimentally derived… Expand
Local alignment statistics.
Publisher Summary This chapter discusses the study of local alignment statistics, the distribution of optimal gapped subalignment scores, and the evidence that two parameters are sufficient to… Expand
A general approach to single-nucleotide polymorphism discovery
Single-nucleotide polymorphisms (SNPs) are the most abundant form of human genetic variation and a resource for mapping complex genetic traits. The large volume of data produced by high-throughput… Expand
Issues in searching molecular sequence databases
Sequence similarity search programs are versatile tools for the molecular biologist, frequently able to identify possible DNA coding regions and to provide clues to gene and protein structure and… Expand
The DNA sequence of human chromosome 7
Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes… Expand