• Publications
  • Influence
The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria.
Although the economics of the pharmaceutical industry continue to restrict investment in novel biomedical responses, action must be taken to avoid the conjunction of factors that promote evolution and spread of antibiotic resistance. Expand
Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution
It is suggested that the relative abundance of the clinical class 1 integron-integrase gene, intI1, is a good proxy for pollution because it is linked to genes conferring resistance to antibiotics, disinfectants and heavy metals. Expand
Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance
It is proposed that environmental aspects of antibiotic-resistance development be included in the processes of any HHRA addressing ARB, and a multicriteria decision analysis approach would be a useful way to undertake an HHRA of environmental antibiotic resistance that informs risk managers. Expand
Impacts of anthropogenic activity on the ecology of class 1 integrons and integron-associated genes in the environment
It is shown that prevalence of class 1 integrons is higher in bacteria exposed to detergents and/or antibiotic residues, specifically in sewage sludge and pig slurry compared with agricultural soils to which these waste products are amended. Expand
The scourge of antibiotic resistance: the important role of the environment.
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. Expand
Prevalence of Sulfonamide Resistance Genes in Bacterial Isolates from Manured Agricultural Soils and Pig Slurry in the United Kingdom
ABSTRACT The prevalences of three sulfonamide resistance genes, sul1, sul2, and sul3 and sulfachloropyridazine (SCP) resistance were determined in bacteria isolated from manured agricultural clayExpand
The dynamic architecture of the metabolic switch in Streptomyces coelicolor
This study provides the first detailed insights into the complex sequence of early regulatory events during and preceding the major metabolic switch in S. coelicolor, which will form the starting point for future attempts at engineering antibiotic production in a biotechnological setting. Expand
Incidence of Class 1 Integrons in a Quaternary Ammonium Compound-Polluted Environment
This is the first study to demonstrate that QAC selection in the natural environment has the potential to coselect for antibiotic resistance, as class 1 integrons are well-established vectors for cassette genes encoding antibiotic resistance. Expand
Waste water effluent contributes to the dissemination of CTX-M-15 in the natural environment
The discovery of the first examples of blaCTX-M-15 in UK river sediment proves that evolution of novel combinations of resistance genes is occurring at high frequency and has to date been significantly underestimated. Expand
Functional metagenomic analysis reveals rivers are a reservoir for diverse antibiotic resistance genes.
The study suggests that waste water disposal increases the reservoir of resistance mechanisms in the environment either by addition of resistance genes or by input of agents selective for resistant phenotypes. Expand