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Metagenomic biomarker discovery and explanation
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses theExpand
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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis
Protecting the Guts Regulatory T cells (Tregs) in the gut are important sentinels in maintaining the peace between our gut and its trillions of resident bacteria and have been shown to be regulatedExpand
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Metagenomic biomarker discovery and explanation
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Host microbiota constantly control maturation and function of microglia in the CNS
As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions.Expand
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Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, but whether thisExpand
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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.
The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of theseExpand
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A single-cell survey of the small intestinal epithelium
We report profiling of 53,193 individual epithelial cells from small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures. Expand
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Activation of Lysosomal Function During Dendritic Cell Maturation
In response to a variety of stimuli, dendritic cells (DCs) transform from immature cells specialized for antigen capture into mature cells specialized for T cell stimulation. During maturation, theExpand
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Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis.
Disruption of homeostasis between the host immune system and the intestinal microbiota leads to inflammatory bowel disease (IBD). Whether IBD is instigated by individual species or disruptions ofExpand
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Developmental Control of Endocytosis in Dendritic Cells by Cdc42
Dendritic cells (DCs) developmentally regulate antigen uptake by controlling their endocytic capacity. Immature DCs actively internalize antigen. However, mature DCs are poorly endocytic, functioningExpand
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