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- Publications
- Influence
Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.
- W. Galloway, J. Hodgkinson, Steven D. Bowden, Martin Welch, D. Spring
- Chemistry, Medicine
- Chemical reviews
- 12 January 2011
Numerous species of bacteria employ a mechanism of intercellular communication known as quorum sensing. This signaling process allows the cells comprising a bacterial colony to coordinate their gene… Expand
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
- W. Galloway, J. Hodgkinson, Steven D. Bowden, M. Welch, D. Spring
- Biology, Medicine
- Trends in microbiology
- 1 September 2012
Quorum sensing is a form of intercellular communication used by many species of bacteria that facilitates concerted interactions between the cells comprising a population. The phenotypes regulated by… Expand
Diversity‐Oriented Synthesis as a Tool for the Discovery of Novel Biologically Active Small Molecules
- W. Galloway, Albert Isidro-Llobet, D. Spring
- Chemistry
- 24 May 2011
Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.
- W. Galloway, Albert Isidro-Llobet, D. Spring
- Biology, Medicine
- Nature communications
- 21 September 2010
Biologically active molecules can be identified through the screening of small-molecule libraries. Deficiencies in current compound collections are evidenced by the continuing decline in… Expand
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes† †Electronic supplementary information (ESI) available. See DOI:…
- Y. Baker, J. Hodgkinson, +7 authors D. Spring
- Biology, Medicine
- Chemical science
- 29 August 2017
Design, synthesis and application of PQS and HHQ probes for investigating quinolone quorum sensing pathways using photoaffinity labeling.
The Basics of Diversity‐Oriented Synthesis
- Kieron M. G. O'Connell, W. Galloway, D. Spring
- Chemistry
- 21 June 2013
In this chapter, the underlying ideas behind diversity-oriented synthesis are introduced. The relationship between diversity-oriented synthesis and combinatorial chemistry is discussed, and the… Expand
Diversity‐Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems
- W. Galloway, David Wilcke, Feilin Nie, Kathy Hadjegeorgiou, Luca Laraia, D. Spring
- Biology
- 27 June 2014
Skeletal diversity construction via a branching synthetic strategy.
A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was… Expand
Diversity-oriented synthesis of macrocyclic peptidomimetics
- Albert Isidro-Llobet, Tiffanie Murillo, +6 authors D. Spring
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 7 March 2011
Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy… Expand
Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.
- E. Wyatt, W. Galloway, +4 authors D. Spring
- Chemistry, Medicine
- Chemical communications
- 16 October 2008
The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of… Expand