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Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.
Numerous species of bacteria employ a mechanism of intercellular communication known as quorum sensing. This signaling process allows the cells comprising a bacterial colony to coordinate their geneExpand
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Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
Quorum sensing is a form of intercellular communication used by many species of bacteria that facilitates concerted interactions between the cells comprising a population. The phenotypes regulated byExpand
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Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.
Biologically active molecules can be identified through the screening of small-molecule libraries. Deficiencies in current compound collections are evidenced by the continuing decline inExpand
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Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes† †Electronic supplementary information (ESI) available. See DOI:
Design, synthesis and application of PQS and HHQ probes for investigating quinolone quorum sensing pathways using photoaffinity labeling.
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The Basics of Diversity‐Oriented Synthesis
In this chapter, the underlying ideas behind diversity-oriented synthesis are introduced. The relationship between diversity-oriented synthesis and combinatorial chemistry is discussed, and theExpand
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Skeletal diversity construction via a branching synthetic strategy.
A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA wasExpand
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Diversity-oriented synthesis of macrocyclic peptidomimetics
Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategyExpand
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Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.
The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor ofExpand
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