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Quantal acetylcholine release at the vertebrate neuromuscular junction.
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The regulation of quantal size.
Quantal size can be altered experimentally by numerous treatments that seem to lack any common thread. The observations may seem haphazard and senseless unless clear distinctions are made from theExpand
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Estimating the timing of quantal releases during end‐plate currents at the frog neuromuscular junction.
1. Following motor nerve stimulation there is a period of greatly enhanced quantal release, called the early release period or ERP (Barrett & Stevens, 1972b). Until now, measurements of theExpand
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Pretreatment with hypertonic solutions increases quantal size at the frog neuromuscular junction.
Miniature end-plate potentials (MEPPs) are increased in size by pretreatment in a hypertonic Ringer. This paper is about the treatments that increase quantal size and the evidence that it occurs byExpand
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Time course and magnitude of effects of changes in tonicity on acetylcholine release at frog neuromuscular junction.
1. The time course for the changes in miniature end-plate potential (min epp) frequency and in epp amplitude produced by alterations in the tonicity of the Ringer at the frog neuromuscular junctionExpand
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The influence of potassium and chloride ions on the membrane potential of single muscle fibers of the crayfish.
Abstract 1. 1. The quick-change method of Hodgkin & Horowicz (1959) was used to estimate transport numbers for K + and Cl − in tonic muscle fibers. 2. 2. The transport number for K + is three to fourExpand
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Loading and recycling of synaptic vesicles in the Torpedo electric organ and the vertebrate neuromuscular junction.
In vertebrate motor nerve terminals and in the electromotor nerve terminals of Torpedo there are two major pools of synaptic vesicles: readily releasable and reserve. The electromotor terminalsExpand
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Facilitation and delayed release at about 0 degree C at the frog neuromuscular junction: effects of calcium chelators, calcium transport inhibitors, and okadaic acid.
1. We studied two-pulse facilitation and delayed release at 0 degree C, because at low temperature facilitation is enhanced and extended whereas delayed release is increased. Our major goal was toExpand
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Transmitter packaging at frog neuromuscular junctions exposed to anticholinesterases; the role of second-stage acetylcholine loading.
1. This investigation was undertaken to explore an unexpected effect of vesamicol, an agent that inhibits active acetylcholine (ACh) uptake into isolated synaptic vesicles. Previous studies at theExpand
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Estimating the time course of evoked quantal release at the frog neuromuscular junction using end‐plate current latencies.
The use of end‐plate current (e.p.c.) latency measurements to estimate the time course of the stochastic probabilistic process governing evoked release was investigated in the sciatic nerve‐sartoriusExpand
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