Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC.
Simulation of DNA Damage after Proton Irradiation
- W. Friedland, P. Jacob, P. Bernhardt, H. Paretzke, M. Dingfelder
- PhysicsRadiation Research
- 1 March 2003
Computer-simulated tracks of energy deposition events from protons and their secondary electrons were superimposed on a higher-order DNA target model describing the spatial coordinates of the whole genome inside a human cell to reproduce the trends in proton-induced DNA DSBs and fragment induction found in recent experiments.
Simulation of DNA fragment distributions after irradiation with photons
- W. Friedland, P. Jacob, H. Paretzke, M. Merzagora, A. Ottolenghi
- PhysicsRadiation and Environmental Biophysics
- 1 May 1999
Simulations of the model of the genome inside a human cell nucleus in its interphase based on the atomic coordinates of the DNA double helix with an additional volume for the water shell show improvements in electron scattering cross-sections for liquid water and the interaction of water radicals with DNA.
Monte Carlo simulation of the production of short DNA fragments by low-linear energy transfer radiation using higher-order DNA models.
A realistic DNA target model that is capable of describing regular solenoidal, crossed-linker or zigzag structures as well as repeating stochastic arrangements of nucleosomes in the chromatin fiber was developed and implemented in the biophysical simulation code PARTRAC.
Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy-relevant energies down to stopping
Track structures and resulting DNA damage in human cells have been simulated for hydrogen, helium, carbon, nitrogen, oxygen and neon ions with 0.25–256 MeV/u energy, and LET-dependencies with pronounced maxima around 100–200 keV/μm occur on nanometre Scale for sites that contain one or more DSB, and on micrometre scale for megabasepair-sized DNA fragments.
Comparisons of Calculations with PARTRAC and NOREC: Transport of Electrons in Liquid Water
- M. Dingfelder, R. H. Ritchie, J. Turner, W. Friedland, H. Paretzke, R. Hamm
- PhysicsRadiation Research
- 1 May 2008
The transport properties of electrons in liquid water using two Monte Carlo computer models, PARTRAC and NOREC, which use interaction cross sections based on plane-wave Born approximations and a numerical parameterization of the complex dielectric response function for the liquid are compared.
Modeling Radiation Chemistry in the Geant4 Toolkit
Mathieu KARAMITROS , Alfonso MANTERO , Sebastien INCERTI , Werner FRIEDLAND , Gerard BALDACCHINO , Philippe BARBERET , Mario BERNAL , Riccardo CAPRA , Christophe CHAMPION , Ziad EL BITAR , Ziad…
Diffusion-controlled reactions modeling in Geant4-DNA
DNA DSB induced in human cells by charged particles and gamma rays: Experimental results and theoretical approaches
- A. Campa, F. Ballarini, M. Tabocchini
- PhysicsInternational Journal of Radiation Biology
- 1 January 2005
The main outcome was that small fragments (<23 kbp) are produced almost exclusively via non-random processes, since their number is considerably higher than that produced by a random insertion of DSB.
Track Structures and Dose Distributions from Decays of 131I and 125I in and around Water Spheres Simulating Micrometastases of Differentiated Thyroid Cancer
It is concluded that, in the treatment of thyroid cancer, the geometrical track structure properties of 125I might be superior to those of 131I in micrometastases with diameters less than 0.1 mm; however, in this medical context, many other factors also have to be considered.