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Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
TLDR
Familial defective apolipoprotein B-100 appears to be a significant genetic cause of hypercholesterolemia in Western societies. Expand
High-resolution analysis of a hypervariable region in the human apolipoprotein B gene.
A hypervariable region occurs immediately 3' of the human apolipoprotein B gene. Several allelic variants of this tandemly repeated sequence can be resolved by genomic blotting. Higher resolutionExpand
Natriuretic peptides and cyclic guanosine 3',5'-monophosphate in asymptomatic and symptomatic left ventricular dysfunction.
TLDR
Although natriuretic peptides and cGMP measured at rest and three minutes after ergometry may be useful for monitoring left ventricular dysfunction they are unlikely to be suitable for more general routine screening for completely asymptomatic left Ventricular dysfunction. Expand
Genetic variation in the apolipoprotein AI-CIII-AIV gene cluster and coronary heart disease.
TLDR
It is suggested that variation associated with some of these RFLPs is contributing to the determination of lipid levels in patients and controls, but that the R FLPs themselves cannot be used as markers for increased coronary risk in the Austrian population. Expand
Relationship between natriuretic peptides and hemodynamics in patients with heart failure at rest and after ergometric exercise.
TLDR
Evidence is provided that BNP might be a better indicator for LVEF at rest than ANP, and BNP correlates very well with MPAP and PAWP, after exercise. Expand
Natriuretic peptides in assessment of left-ventricular dysfunction.
TLDR
There is now sufficient evidence to encourage physicians to gain experience with NP as a supplement in the diagnosis of patients suspected of having heart failure, and BNP has an excellent negative predictive value particularly in high risk patients. Expand
A deletion polymorphism in the angiotensin converting enzyme gene is not associated with coronary heart disease in an Austrian population.
TLDR
It is concluded that the insertion/deletion polymorphism in the ACE gene cannot be used as a marker for coronary risk assessment in the Austrian population and was not able to show a significant association with coronary heart disease in subgroups containing patients considered at low coronary risk. Expand
Hypervariability in a minisatellite 3' of the apolipoprotein B gene in patients with coronary heart disease compared with normal controls.
TLDR
High-resolution method was used to study the allele frequencies of a hypervariable minisatellite region close to the apolipoprotein B gene in 110 patients with severe coronary disease and in 117 normal controls, finding that alleles containing 38, 44, 46, or 48 hypervariable elements showed an association with coronary heart disease. Expand
Apolipoprotein B gene mutations in Austrian subjects with heart disease and their kindred.
TLDR
Pedigree analysis of the two probands' families established a correlation between the apolipoprotein (apo) B mutation, defective LDL, and a particular apo B haplotype that was characterized by 10 apO B gene markers. Expand
Insertion/deletion polymorphism in the angiotensin-converting enzyme gene is associated with atrial natriuretic peptide activity after exercise.
TLDR
It is hypothesized that the result might represent a variability gene effect of the ACE gene locus on endocrine processes in the heart during exposure to physical stress. Expand
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