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Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion.
All experts agreed that anticoagulation should be urgently reversed, but how to achieve it varied from use of prothrombin complex concentrates only to recombinant factor VIIa only, and all experts favored resumption of warfarin therapy within 3 to 10 days of ICH in stable patients in whom subsequent antICOagulation is mandatory. Expand
Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial
This study assessed whether minimally invasive catheter evacuation followed by thrombolysis (MISTIE), with the aim of decreasing clot size to 15 mL or less, would improve functional outcome in patients with intracerebral haemorrhage. Expand
Refractory and Super-Refractory Status Epilepticus—an Update
The approach to refractorystatus epilepticus and super-refractory status epileptus is reviewed, including management as well as common pathophysiological causes of these entities. Expand
The authors’ study is important for clinicians, since all myoclonic jerking seen at the bedside after CA should not be interpreted as indicative of myoclonus status epilepticus without EEG confirmation, since to do so could lead to a self-fulfilling prophecy of poor outcome and untreated status epileptus. Expand
Neuron-specific enolase correlates with other prognostic markers after cardiac arrest.
Cronberg et al.1 reported serum NSE levels >33 μg/L to be highly predictive of death after CA treated with hypothermia, and to correlate with abnormal diffusion-weighted imaging (DWI), abnormalExpand
Prediction of potential for organ donation after cardiac death in patients in neurocritical state: a prospective observational study
The DCD-N score can be used to predict potential candidates for DCD in patients with non-survivable brain injury, however, this score needs to be tested specifically in a cohort of potential donors participating in DCD protocols. Expand
Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage.
Intravenous bolus administration of rFVIIa can rapidly lower the international normalized ratio and appears to be safe for patients with warfarin-related ICH. Expand
Management of Intracranial Pressure
Management of elevated ICP is, in part, dependent on the underlying cause and medical options for treating raised ICP include head of bed elevation, IV mannitol, hypertonic saline, transient hyperventilation, barbiturates, and, if ICP remains refractory, sedation, endotracheal intubation, mechanical ventilation, and neuromuscular paralysis. Expand
Intracranial Hemorrhage Following Neuroendovascular Procedures with Abciximab is Associated with High Mortality: A Multicenter Series
Adjunctive use of abciximab to prevent or treat ischemic sequelae during neuroendovascular procedures is associated with a high risk of ICH, and 9 patients died following ICH with 44% mortality. Expand
Validation of frontal near-infrared spectroscopy as noninvasive bedside monitoring for regional cerebral blood flow in brain-injured patients.
OBJECT Near-infrared spectroscopy (NIRS) offers noninvasive bedside measurement of direct regional cerebral arteriovenous (mixed) brain oxygenation. To validate the accuracy of this monitoringExpand