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Response of serum interleukin-6 in patients undergoing elective surgery of varying severity.
1. Recent studies have suggested that interleukin-6 is a major mediator of the acute-phase protein response in man. The aim of the present study was to investigate the relationships between the… Expand
Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study.
- M. Mannstadt, B. Clarke, +10 authors J. Bilezikian
- The lancet. Diabetes & endocrinology
- 1 December 2013
BACKGROUND Hypoparathyroidism results in impaired mineral homoeostasis, including hypocalcaemia and hyperphosphataemia. Treatment with high-dose oral calcium and active vitamin D does not provide… Expand
Genome wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget’s disease of bone
- Omar M E Albagha, M. R. Visconti, +14 authors S. Ralston
- Biology, Medicine
- Nature Genetics
- 17 March 2010
Paget's disease of bone (PDB) is a common disorder with a strong genetic component characterized by focal increases in bone turnover, which in some cases is caused by mutations in SQSTM1. To identify… Expand
Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets.
- Doron Bresler, J. Bruder, K. Mohnike, W. Fraser, P. Rowe
- Chemistry, Medicine
- The Journal of endocrinology
- 1 December 2004
MEPE (Matrix Extracellular PhosphoglycoprotEin) expression is markedly elevated in X-linked-hypophosphatemic-rickets (HYP) and tumor-induced osteomalacia (TIO). In normal individuals, circulating… Expand
Periodontal disease and adverse pregnancy outcomes : A systematic review
Increasing evidence implicates periodontal disease as a factor associated with such systemic disorders as myocardial infarction, stroke, and diabetes. Adverse pregnancy outcomes also have been… Expand
Dietary patterns, bone resorption and bone mineral density in early post-menopausal Scottish women
- A. C. Hardcastle, L. Aucott, W. Fraser, D. Reid, H. Macdonald
- European Journal of Clinical Nutrition
- 1 March 2011
Background/Objectives:Several nutrients affect bone turnover. Dietary patterns may provide insights into which foods are important and how nutrition affects bone health. The aim of this study was to… Expand
A Detailed Assessment of Alterations in Bone Turnover, Calcium Homeostasis, and Bone Density in Normal Pregnancy
- A. Black, J. Topping, B. Durham, R. Farquharson, W. Fraser
- Journal of bone and mineral research : the…
- 1 March 2000
The effects of pregnancy on bone turnover and the potential risk of developing an osteoporotic fracture in pregnancy are controversial. Utilizing biochemical markers of bone formation and resorption… Expand
The Marine System of the Western Antarctic Peninsula
The Ecosystems Center, MBL, Woods Hole, MA, USA British Antarctic Survey, Cambridge, UK Virginia Instute of Marine Science, College of William and Mary, Gloucester Point, VA, USA Woods Hole… Expand
Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT.
- A. Wood, K. Secombes, +7 authors H. Macdonald
- The Journal of clinical endocrinology and…
- 3 August 2012
CONTEXT Observational studies show an association between low vitamin D status assessed by circulating 25-hydroxyvitamin D and cardiovascular events and mortality. Data from randomized controlled… Expand
Vitamin D Assays: Past and Present Debates, Difficulties, and Developments
Clinical interest in Vitamin D and its purported roles not only in calcium and bone metabolism but in several other medical conditions (diabetes, cardiovascular disease, multiple sclerosis, cancer,… Expand