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RHD positive haplotypes in D negative Europeans
BackgroundBlood group genotyping is increasingly utilized for prenatal diagnosis and after recent transfusions, but still lacks the specificity of serology. In whites, the presence of antigen D isExpand
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Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I.
Interaction of endotoxin (lipopolysaccharide [LPS]) with human lipoproteins is known to prevent the LPS-induced activation of human monocytes and release of cytokines (monokines). LPS was exposed toExpand
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Molecular genetics and clinical applications for RH.
  • W. Flegel
  • Medicine, Biology
  • Transfusion and apheresis science : official…
  • 1 February 2011
Rhesus is the clinically most important protein-based blood group system. It represents the largest number of antigens and the most complex genetics of the 30 known blood group systems. The RHD andExpand
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How I manage donors and patients with a weak D phenotype
  • W. Flegel
  • Biology, Medicine
  • Current opinion in hematology
  • 1 November 2006
Purpose of reviewSince the adoption of molecular blood-group typing, the considerable heterogeneity of the serologic entities weak D and DEL at the molecular level has come to light. I offer anExpand
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An epidemiologic survey of human alveolar echinococcosis in southwestern Germany. Römerstein Study Group.
The inhabitants of a rural community in southwestern Germany were examined for alveolar echinococcosis (AE). The study was prompted by the recent increase of the prevalence of the parasite in foxesExpand
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The DAU allele cluster of the RHD gene.
Variant D occurs frequently in Africans. However, considerably less RHD alleles have been described in this population compared with Europeans. We characterized 5 new RHD alleles, dubbed DAU-0 toExpand
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Molecular basis of weak D phenotypes.
A Rhesus D (RhD) red blood cell phenotype with a weak expression of the D antigen occurs in 0.2% to 1% of whites and is called weak D, formerly Du. Red blood cells of weak D phenotype have a muchExpand
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DNB: a partial D with anti-D frequent in Central Europe.
To improve routine D typing and define transfusion strategy, it is important to establish the frequency of partial D alleles and their susceptibility to anti-D alloimmunization due to transfusion orExpand
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RHD gene deletion occurred in the Rhesus box.
The Rh blood group antigens derive from 2 genes, RHD and RHCE, that are located at chromosomal position 1p34.1-1p36 (chromosome 1, short arm, region 3, band 4, subband 1, through band 6). In whites,Expand
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Molecular biology of partial D and weak D: implications for blood bank practice.
Two genes, RHD and RHCE, encode the antigens of the RH blood group system. The clinically most important antigen D is determined by the presence of a functional and grossly normal RHD gene. About 18%Expand
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