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Acetylcholine synthesis in different regions of the central nervous system
It has been shown that this enzyme can be extracted from acetone-dried tissue and that such extracts form large amounts of acetylcholine in the presence of KCI, MgCl2, choline, cysteine, citrate and adenosine-triphosphate.
Penetration of bromophenol blue from the perfused cerebral ventricles into the brain tissue
Scratching movements evoked by drugs applied to the upper cervical cord
It was suggested that bromophenol blue had a central excitatory action when present in the subarachnoid space but not when passing through the cerebral ventricles or the aqueduct.
Vasodepressor effects obtained by drugs acting on the ventral surface of the brain stem.
It is concluded that the ventral surface of the medulla contains at least two bilateral areas from which vasodepressor effects are obtained on topical application of drugs: a more caudally situated one which is sensitive to nicotine, but insensitive to glycine and pentobarbitone sodium; a more rostrally situatedOne which is insensitive to nicotine but sensitive to glycines, and both areas are sensitive to carbachol and physostigmine.
The mechanism of the sting of the common nettle (urtica urens)
VASOPRESSIN RELEASE BY NICOTINE: THE SITE OF ACTION
- G. Bisset, W. Feldberg, P. Guertzenstein, M. Silva
- Biology, MedicineBritish journal of pharmacology
- 1 August 1975
It is concluded that nicotine acts on the ventral surface of the brain stem probably by activating the central projection to the supra‐optic and possibly also the paraventricular nuclei of afferent pathways in the sinus and vagus nerves which control the release of vasopressin in response to changes in blood volume or distribution.
Injections of drugs into the lateral ventricle of the cat
The method formerly used for intraventricular injections in unanaesthetized animals has the following drawbacks: the animals are physically restrained; fear, pain and other defence reactions may overshadow or modify the drug effect; and there must always remain a certain doubt whether injury of the brain substance has occurred and is responsible for the observed effects.
The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin
The present experiments show that bradykinin and angiotensin are potent releasers of the medullary hormones, probably mainly adrenaline, from the suprarenal glands. Angiotensin is more potent in this…
Pyrogen fever and prostaglandin‐like activity in cerebrospinal fluid
Samples of c.s.f. were collected from the same cat, during normal temperature, during fever produced by Shigella dysenteriae injected into the third ventricle and during the fall in temperature which occurred when the antipyretic paracetamol was injected intraperitoneally during the pyrogen fever.
Effects of ganglion‐blocking substances on the small intestine
- W. Feldberg
- BiologyThe Journal of physiology
- 28 May 1951