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Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent.
Antimicrobial cationic peptides are of interest because they can combat multi-drug-resistant microbes. Most peptides form alpha-helices or beta-sheet-like structures that can insert into and… Expand
Nanoparticles for tumor targeted therapies and their pharmacokinetics.
Various types of nanoparticles, such as liposomes, polymeric micelles, dendrimers, superparamagnetic iron oxide crystals, and colloidal gold, have been employed in targeted therapies for cancer. Both… Expand
Estrogen receptor alpha mediates breast cancer cell resistance to paclitaxel through inhibition of apoptotic cell death.
Estrogen receptors (ER) are expressed in approximately 65% of human breast cancer. Cumulative data from clinical trials and retrospective analyses suggest that some chemotherapeutic agents may be… Expand
Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey
BackgroundThe exact pathogenic mechanism of knee osteoarthritis (OA) is still unknown. With the exception of clinical treatment to alleviate symptoms, or total knee replacement, there is currently no… Expand
New process control strategy used in a rapamycin fermentation
Abstract A high antibiotic expression level was obtained in a pilot-scale fermentation process with Streptomyces. With a new supervisory computer control algorithm, the agitation, aeration rate,… Expand
Possible mechanisms of paclitaxel-induced apoptosis.
- W. Fan
- Chemistry, Medicine
- Biochemical pharmacology
- 1 June 1999
Paclitaxel, a naturally occurring antimicrotubule agent, has been demonstrated to possess significant cell-killing activity in a variety of tumor cells through induction of apoptosis. It is currently… Expand
α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
BackgroundAlthough evidence suggests that the prevalence of Parkinson’s disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear.… Expand
The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis.
Cationic antimicrobial peptides have received considerable interest as new therapeutics with the potential for treatment of multiple-drug resistant infections. We recently reported that… Expand
Estrogen Receptor α Mediates Breast Cancer Cell Resistance to Paclitaxel through Inhibition of Apoptotic Cell Death
Estrogen receptors (ER) are expressed in ∼65% of human breast cancer. Cumulative data from clinical trials and retrospective analyses suggest that some chemotherapeutic agents may be less effective… Expand
Nuclear factor-kappaB/IkappaB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells.
Paclitaxel (Taxol), a naturally occurring antimitotic agent, has shown significant cell-killing activity in a variety of tumor cells through induction of apoptosis. The mechanism by which paclitaxel… Expand