W. F. Fricke

Publications84
h-index34
Citations6,176
Highly Influential Citations417
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Genome sequence of the bioplastic-producing “Knallgas” bacterium Ralstonia eutropha H16
TLDR
The complete genome sequence of the two chromosomes of R. eutropha H16 is reported, offering the genetic basis for exploiting the biotechnological potential of this organism and providing insights into its remarkable metabolic versatility. Expand
Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans
TLDR
The genome project revealed the unique biochemistry of G. oxydans with respect to the process of incomplete oxidation and revealed many membrane-bound dehydrogenases that are critical for the incomplete oxidation of biotechnologically important substrates. Expand
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models
TLDR
SIGI-HMM is a sensitive tool for the identification of GIs in microbial genomes that allows to interactively analyze genomes in detail and to generate or to test hypotheses about the origin of acquired genes. Expand
The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates.
TLDR
Pangenomic calculations indicate that E. coli genomic diversity represents an open pangenome model containing a reservoir of more than 13,000 genes, many of which may be uncharacterized but important virulence factors, which should provide the basis for future functional work on this important group of pathogens. Expand
Multiple Antimicrobial Resistance in Plague: An Emerging Public Health Risk
TLDR
These studies reveal that this common plasmid backbone is broadly disseminated among MDR zoonotic pathogens associated with agriculture and has the potential to disseminate to Y. pestis and other human and zoonosis bacterial pathogens and therefore represents a significant public health concern. Expand
The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features
TLDR
The genome sequence of C. kluyveri was reported, which revealed new insights into the metabolic capabilities of this well studied organism and suggested that the two enzymes, which are isolated together in a macromolecular complex, form a carboxysome-like structure. Expand
Comparative genomics of the IncA/C multidrug resistance plasmid family.
TLDR
A hipAB toxin-antitoxin gene cluster found on pRA1, which in Escherichia coli is involved in the formation of persister cell subpopulations, suggests persistence as an early broad-spectrum antimicrobial resistance mechanism in the evolution of IncA/C resistance plasmids. Expand
The genome sequence of Clostridium tetani, the causative agent of tetanus disease
TLDR
Comparative genomics with the genomes of Clostridium perfringens, the causative agent of gas gangrene, and Clostridgeium acetobutylicum, a nonpathogenic solvent producer, revealed a remarkable capacity of C. tetani: the organism can rely on an extensive sodium ion bioenergetics. Expand
The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis.
TLDR
Four sets of mtaABC genes coding for methanol:coenzyme M methyltransferases were found in the genome of M. stadtmanae and exhibit homology to mta genes previously identified in Methanosarcina species, which explains why this archaeon is dependent on acetate for biosynthesis of cell components. Expand
Colonization patterns of soil microbial communities in the Atacama Desert
TLDR
The results suggest that microorganisms in the driest soils of the Atacama Desert are in a state of stasis for most of the time, but can potentially metabolize if presented with liquid water for a sufficient duration. Expand
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