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Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin.
TLDR
The antioxidant capacity of the human epidermis is far greater than that of dermis, as it acts as the initial barrier to oxidant assault, and it is perhaps not surprising that it has higher levels of antioxidants. Expand
The regressing thin malignant melanoma. A distinctive lesion with metastatic potential
TLDR
It is submitted that patients whose malignant melanomas display regression be followed rigorously for evidence of metastases irrespective of the tumor's actual measured thickness or level of invasion, as a significant caveat to the current histologic staging system that equates thinness with low risk. Expand
Absorption kinetics of griseofulvin in man.
TLDR
The distribution and elimination kinetics of griseofulvin have been examined in man via a saline drip and it was shown that the area under the plasma-concentration time curve was proportional to the dose administered. Expand
Atrophic Striae in Patients with Inguinal Intertrigo: Pathogenesis
TLDR
It is suggested that the initial change is nonunion of groups of connective tissue fibrils for elastic tissue, and the possibility is raised that local inflammation and topically applied corticosteroids may influence the production of striae. Expand
Cutaneous changes in the porphyrias. A microscopic study.
TLDR
Results indicated that the vascular abnormality was due to structural alterations as well as deposition of materials from the circulation, and distribution of the changes emphasizes the importance of the prophyrins and sunlight in development of the cutaneous damage noted in these porphyric states. Expand
Thrombomodulin expression on dermal cells in normal and psoriatic skin
TLDR
Thrombomodulin + dermal cells and factor XIIIa + dendrocytes were frequently seen close together and could act cooperatively to regulate extravascular thrombin homeostasis in both normal and pathological dermal environments. Expand
Nuclear changes during keratinization of normal human epidermis.
TLDR
The study of the granular cell nucleus shows changes correlated with the cytoplasmic differentiation: with accumulation of cytopLasmic keratohyalin, the nucleus becomes flattened and the nuclear membrane becomes indented. Expand
Treatment of warts with cantharidin.
TLDR
Because of the special ability of cantharidin to disorganize epidermal cells, its use as a chemotherapeutic agent in warts is explored. Expand
Soluble dipeptidyl peptidase IV from terminal differentiated rat epidermal cells: purification and its activity on synthetic and natural peptides.
TLDR
In terminally differentiated epidermal cells dipeptidyl peptidase IV (EC 3.5) (DPP IV) is present mainly in a soluble form and a stoichiometric reaction of the enzyme on substance P was observed. Expand
Griseofulvin levels in stratum corneum. Study after oral administration in man.
TLDR
Findings emphasize that stratum corneum can act as a compartment for drugs such as griseofulvin, and there is a more rapid buildup of drug after oral administration than thought previously. Expand
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