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Homogeneous uridine kinase from Ehrlich ascites tumor: substrate specificity and inhibition by bisubstrate analogs.
Uridine kinase has been purified to homogeneity from Ehrlich ascites tumor cells and shows substrate specificity only for ribopyrimidine nucleosides and is active with various analogs that have limited structural alterations; both endocyclic and exocyclics substituents can be acceptable. Expand
Sites of P element insertion and structures of P element deletions in the 5' region of Drosophila melanogaster RpII215.
The sequences of four revertants of one P element insertion mutation (D50) indicate that the P element is either precisely deleted or internally deleted to restore RpII215 activity. Expand
Effects of [(N-alkyl-1,3-dioxo-1H,3H-isoindolin-5-yl)oxy]alkanoic acids, [(N-alkyl-1-oxo-1H,3H-isoindolin-5-yl)oxy]butanoic acids, and related derivatives on chloride influx in primary astroglial
Derivatives with acid side chains of four carbons demonstrated superior activity to those of two carbons and larger substituents such as cyclopentyl and cyclohexyl are less active and Halogen substitution on the aromatic ring did not enhance activity. Expand
Effects of [(N-alkyl-1,3-dihydro-1-oxoisoindolin-5-yl)oxy]alkanoic acids on chloride transport in primary astroglial cultures.
The 4-chloro-substituted 1-oxoisoindolines and four-carbon acid side chain derivatives were more active than the three- and two-carbon analogs and the compounds were found to exhibit a similar profile to that of furosemide by inhibiting both transporters. Expand
Conformational Analysis, Molecular Modeling, and Quantitative Structure–Activity Relationship Studies of Agents for the Inhibition of Astrocytic Chloride Transport
Comparative molecular field analysis (CoMFA) was utilized as a three-dimensional QSAR technique to explore changes in the steric and electrostatic fields of the molecules that can account for differences in biological activity values. Expand