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Neurobiology of emotion perception I: the neural basis of normal emotion perception
Subgenual prefrontal cortex abnormalities in mood disorders
Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
Because the MPFC and related limbic structures provide forebrain modulation over visceral control structures in the hypothalamus and brainstem, their dysfunction can account for the disturbances in autonomic regulation and neuroendocrine responses that are associated with mood disorders.
Neurobiology of emotion perception II: implications for major psychiatric disorders
Neurocircuitry of Mood Disorders
A system has been described that links the medial prefrontal cortex and a few related cortical areas to the amygdala, the ventral striatum and pallidum, the medial thalamus, the hypothalamus, and the periaqueductal gray and other parts of the brainstem, which indicates that this system is centrally involved in mood disorders.
Neuroimaging studies of mood disorders
- W. Drevets
- Psychology, MedicineBiological Psychiatry
- 15 October 2000
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
- W. Drevets
- Psychology, BiologyCurrent Opinion in Neurobiology
- 1 April 2001
Glial reduction in the subgenual prefrontal cortex in mood disorders.
- D. Ongür, W. Drevets, J. Price
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 27 October 1998
The cellular composition of area sg24 in two different sets of brains was examined to identify a biological marker associated with familial mood disorders that may provide important clues regarding the pathogenesis of these common psychiatric conditions.
Discovering Endophenotypes for Major Depression
The case is made for the development of a new classification system in order to reduce the heterogeneity of depression representing a major impediment to elucidating the genetic and neurobiological basis of this common, severe, and often life-threatening illness.
The cellular neurobiology of depression
This work has shown that antagonists designed to directly target molecules in signaling pathways that regulate neuroplasticity and cell survival in major depressive disorders may hold promise as new therapeutics for depression.