• Publications
  • Influence
Neurobiology of emotion perception I: the neural basis of normal emotion perception
TLDR
It is suggested that the extent to which a stimulus is identified as emotive and is associated with the production of an affective state may be dependent upon levels of activity within these two neural systems. Expand
Subgenual prefrontal cortex abnormalities in mood disorders
TLDR
Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives. Expand
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
TLDR
Because the MPFC and related limbic structures provide forebrain modulation over visceral control structures in the hypothalamus and brainstem, their dysfunction can account for the disturbances in autonomic regulation and neuroendocrine responses that are associated with mood disorders. Expand
Neurobiology of emotion perception II: implications for major psychiatric disorders
TLDR
It is suggested that distinct patterns of structural and functional abnormalities in neural systems important for emotion processing are associated with specific symptoms of schizophrenia and bipolar and major depressive disorder. Expand
Neurocircuitry of Mood Disorders
TLDR
A system has been described that links the medial prefrontal cortex and a few related cortical areas to the amygdala, the ventral striatum and pallidum, the medial thalamus, the hypothalamus, and the periaqueductal gray and other parts of the brainstem, which indicates that this system is centrally involved in mood disorders. Expand
Neuroimaging studies of mood disorders
  • W. Drevets
  • Medicine, Psychology
  • Biological Psychiatry
  • 15 October 2000
TLDR
Findings implicate interconnected neural circuits in which pathologic patterns of neurotransmission may result in the emotional, motivational, cognitive, and behavioral manifestations of primary and secondary affective disorders. Expand
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
  • W. Drevets
  • Medicine, Psychology
  • Current Opinion in Neurobiology
  • 1 April 2001
TLDR
Data suggest a role for dysfunction within the prefrontal cortical and striatal systems that normally modulate limbic and brainstem structures involved in mediating emotional behavior in the pathogenesis of depressive symptoms. Expand
Glial reduction in the subgenual prefrontal cortex in mood disorders.
TLDR
The cellular composition of area sg24 in two different sets of brains was examined to identify a biological marker associated with familial mood disorders that may provide important clues regarding the pathogenesis of these common psychiatric conditions. Expand
The cellular neurobiology of depression
TLDR
This work has shown that antagonists designed to directly target molecules in signaling pathways that regulate neuroplasticity and cell survival in major depressive disorders may hold promise as new therapeutics for depression. Expand
A functional anatomical study of unipolar depression
TLDR
Evidence suggests that a circuit involving the prefrontal cortex, amygdala, and related parts of the striatum, pallidum, and medial thalamus is involved in the functional neuroanatomy of depression. Expand
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