W. Doolittle

Publications341
h-index79
Citations25,624
Highly Influential Citations1,172
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A kingdom-level phylogeny of eukaryotes based on combined protein data.
Current understanding of the higher order systematics of eukaryotes relies largely on analyses of the small ribosomal subunit RNA (SSU rRNA). Independent testing of these results is still limited. We… Expand
  • 1,175
  • 62
Selfish genes, the phenotype paradigm and genome evolution
Natural selection operating within genomes will inevitably result in the appearance of DNAs with no phenotypic expression whose only ‘function’ is survival within genomes. Prokaryotic transposable… Expand
  • 1,637
  • 55
The complete genome of the crenarchaeon Sulfolobus solfataricus P2
The genome of the crenarchaeon Sulfolobus solfataricus P2 contains 2,992,245 bp on a single chromosome and encodes 2,977 proteins and many RNAs. One-third of the encoded proteins have no detectable… Expand
  • 765
  • 49
  • PDF
Prokaryotic evolution in light of gene transfer.
Accumulating prokaryotic gene and genome sequences reveal that the exchange of genetic information through both homology-dependent recombination and horizontal (lateral) gene transfer (HGT) is far… Expand
  • 898
  • 43
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Use of 16S rRNA and rpoB Genes as Molecular Markers for Microbial Ecology Studies
ABSTRACT Several characteristics of the 16S rRNA gene, such as its essential function, ubiquity, and evolutionary properties, have allowed it to become the most commonly used molecular marker in… Expand
  • 532
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  • PDF
Archaea and the prokaryote-to-eukaryote transition.
Since the late 1970s, determining the phylogenetic relationships among the contemporary domains of life, the Archaea (archaebacteria), Bacteria (eubacteria), and Eucarya (eukaryotes), has been… Expand
  • 481
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  • PDF
Microsporidia are related to Fungi: evidence from the largest subunit of RNA polymerase II and other proteins.
We have determined complete gene sequences encoding the largest subunit of the RNA polymerase II (RBP1) from two Microsporidia, Vairimorpha necatrix and Nosema locustae. Phylogenetic analyses of… Expand
  • 492
  • 26
Comparison of Bayesian and maximum likelihood bootstrap measures of phylogenetic reliability.
Owing to the exponential growth of genome databases, phylogenetic trees are now widely used to test a variety of evolutionary hypotheses. Nevertheless, computation time burden limits the application… Expand
  • 470
  • 25
  • PDF
Phylogenetic analyses of cyanobacterial genomes: quantification of horizontal gene transfer events.
Using 1128 protein-coding gene families from 11 completely sequenced cyanobacterial genomes, we attempt to quantify horizontal gene transfer events within cyanobacteria, as well as between… Expand
  • 303
  • 25
You are what you eat: a gene transfer ratchet could account for bacterial genes in eukaryotic nuclear genomes.
  • W. Doolittle
  • Biology, Medicine
  • Trends in genetics : TIG
  • 1 December 1998
Recent phylogenetic analyses reveal that many eukaryotic nuclear genes whose prokaryotic ancestry can be pinned down are of bacterial origin. Among them are genes whose products function exclusively… Expand
  • 548
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