Share This Author
In vitro mutagenicity of valepotriates
The valepotriates were mutagenic for TA100, WP2 and WP2 uvrA− at concentrations up to about 1.0 μmole/plate when S9-mix was added to the test system and were toxic in the presence of a metabolic activation system for all strains tested.
Hereditary median dermoid cysts of the nose.
Quantitative structure-activity analysis in a series of antimycotically active N-hydroxypyridones.
Contribution to the methodology of testing topical antimycotic agents in guinea pig dermatophytosis
- W. Dittmar
- Biology, MedicineMykosen
- 1 August 1975
A description is given of a simple technique which may be regarded as an in vivo analogue to the mycelial growth test on agar media which demonstrates a good activity of ciclopirox (HOE 296).
Hansch analysis in a series of substances with antifungal activity.
For some time we have been studying substances of the following type, that exhibit an interesting antifungal activity: Open image in new window
Considerations on the carcinogenicity of the mushroom poison gyromitrin and its metabolites
Since the hydrolysis rate of MFH, to produce MMH, is low, it is concluded that MFH must be activated in vivo into toxic metabolites which are ultimately responsible for the known high carcinogenicity ofMFH.
Inhibition of nucleoside uptake into Ehrlich ascites carcinoma cells by new cytostatic methylhydrazones.
New hydrazones were synthesized in which the beta-chloroethyl group was replaced by substituents conveying a partial positive charge at the N' moiety by induction and/or mesomerism, and in a preliminary antitumor evaluation showed a cytostatic activity in vivo similar to that of the Beta- chloroethyl hydrazone.
Influence of valtrate/isovaltrate on the hematopoiesis and metabolic liver activity in mice in vivo.
Toxic effects of valtrate in vivo is restricted because the distribution of the drug via circulation is obviously small, and the effect of valTrate on the ability of the liver to metabolize [14)C]methacetin was investigated.
On interactions of cytostatic benzylidine hydrazines with SH-groups.
Mutagenic activity of cytostatic methyl hydrazones with different strains of Salmonella typhimurium
No relation could be detected between the mutagenic properties of the methyl-hydrazones and their alkylating behaviour on 4-(4-nitrobenzyl)-pyridine, and all four hydrazones are Mutagenic per se without a metabolic activation through rat liver microsomes.