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A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents
Exosomes play a role in cell-to-cell signaling and serve as possible biomarkers. Isolating exosomes with reliable quality and substantial concentration is a major challenge. Our purpose is to compareExpand
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Human aqueous humor exosomes.
Aqueous humor (AH) is a dynamic intraocular fluid that supports the vitality of tissues that regulate intraocular pressure. We recently discovered that extracellular nanovesicles called exosomes areExpand
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Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.
Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow resistance and thus intraocular pressure; andExpand
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Roles of exosomes in the normal and diseased eye
&NA; Exosomes are nanometer‐sized vesicles that are released by cells in a controlled fashion and mediate a plethora of extra‐ and intercellular activities. Some key functions of exosomes includeExpand
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Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork.
PURPOSE Nitric oxide (NO) increases the rate at which aqueous humor exits the eye; however, the involvement of soluble guanylate cyclase (sGC) is unknown. This study investigated the role of sGC inExpand
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NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel.
Nitric oxide (NO) donors decrease intraocular pressure (IOP) by increasing aqueous outflow facility in the trabecular meshwork (TM) and/or Schlemm's canal. However, the cellular mechanisms areExpand
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Endogenous regulation of human Schlemm's canal cell volume by nitric oxide signaling.
PURPOSE There is a time-course correlation between nitric oxide (NO)-induced decreases in trabecular meshwork (TM) cell volume and NO-induced increases in outflow facility. The Schlemm's canal (SC)Expand
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Activation of the BK(Ca) channel increases outflow facility and decreases trabecular meshwork cell volume.
  • W. Dismuke, D. Ellis
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics…
  • 3 August 2009
PURPOSE Inhibition of the BK(Ca) channel attenuated the nitric oxide-induced increase in outflow facility and decrease in trabecular meshwork (TM) cell volume suggesting the involvement of the BK(Ca)Expand
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Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain.
Myocilin is a widely expressed protein with no known function; however, mutations in myocilin appear to manifest uniquely as ocular hypertension and the blinding disease of glaucoma. Using theExpand
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Peptide‐Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite‐Mediated Nitration
Nitric oxide (NO) is a free radical signaling molecule that plays a crucial role in modulating physiological homeostasis across multiple biological systems. NO dysregulation is linked to theExpand
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