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Hoarding in obsessive-compulsive disorder: clinical and genetic correlates.
OBJECTIVE Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptakeExpand
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Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 17 glucocorticoid receptor promoter region
Separating rat pups from their mothers during the early stages of life is an animal model commonly used to study the development of psychiatric disorders such as anxiety and depression. The presentExpand
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The effect of electromagnetic radiation in the mobile phone range on the behaviour of the rat
Electromagnetic radiation (EMR) is emitted from electromagnetic fields that surround power lines, household appliances and mobile phones. Research has shown that there are connections between EMRExpand
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Brain-Derived Neurotrophic Factor: The Neurotrophin Hypothesis of Psychopathology
ABSTRACT While monoaminergic hypotheses of psychopathology remain popular, there has been growing interest in the role of neurotrophins in neuropsychiatric disorders. Basic laboratory work hasExpand
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Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats
Early life stress in humans can affect the development of neurons and neurotransmitter systems and predispose an individual to the subsequent development of depression. Similarly, in rats, maternalExpand
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Animal models of anxiety disorders
Animal models may be useful in investigating the fundamental mechanisms underlying psychiatric disorders, and may contribute to the development of new medications. A computerized literature searchExpand
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A proteomic analysis of the ventral hippocampus of rats subjected to maternal separation and escitalopram treatment
Early life stress is known to predispose humans to the development of depression. Developmental stress has been shown to cause various changes in neurotransmitter systems, neurotrophin expression andExpand
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Normative data for the Tygerberg Cognitive Battery and Mini-Mental Status Examination in a South African population.
BACKGROUND Normative data for the Tygerberg Cognitive Battery (TCB) and Mini-Mental Status Examination (MMSE) (in South Africa) have not been formally examined before. The TCB was developed for theExpand
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Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: Reversal by escitalopram
Early exposure to adverse experiences may lead to specific changes in hippocampal glucocorticoid function resulting in abnormalities within the hypothalamic-adrenal axis. Given interactions betweenExpand
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Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model
Early adverse life events, followed by subsequent stressors, appear to increase susceptibility for subsequent onset of psychiatric disorders in humans. The molecular mechanisms that underlie thisExpand
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