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Duodenal infusion of donor feces for recurrent Clostridium difficile.
The infusion of donor feces was significantly more effective for the treatment of recurrent C. difficile infection than the use of vancomycin and patients showed increased fecal bacterial diversity, similar to that in healthy donors, with an increase in Bacteroidetes species and clostridium clusters IV and XIVa and a decrease in Proteobacteria species.
Complete genome sequence of Lactobacillus plantarum WCFS1
- M. Kleerebezem, J. Boekhorst, R. Siezen
- BiologyProceedings of the National Academy of Sciences…
- 3 February 2003
The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated from human saliva, has been determined, and contains 3,052 predicted protein-encoding genes, suggesting that these genes form a lifestyle adaptation region in the chromosome.
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
- A. Everard, C. Belzer, Patrice D Cani
- BiologyProceedings of the National Academy of Sciences
- 13 May 2013
Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.
Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria
The results indicate that the combination of cloning and TGGE analysis of 16S rDNA amplicons is a reliable approach to monitoring different microbial communities in feces.
Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin
- P. D. de Ruyter, O. Kuipers, W. D. de Vos
- BiologyApplied and environmental microbiology
- 1 October 1996
The kinetics, control, and efficiency of nisin-induced expression directed by the nisA promoter region were studied in Lactococcus lactis with transcriptional and translational fusions to the gusA reporter genes, illustrating the potential of the nisi-inducible expression system for overproduction of desired proteins.
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.
Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased along with levels of butyrate-producing intestinal microbiota, and intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans.
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Evidence is provided for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system, because of its crucial role in the host physiology and health status.
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.
Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction (*)
- O. Kuipers, M. Beerthuyzen, P. D. de Ruyter, E. Luesink, W. D. de Vos
- BiologyThe Journal of Biological Chemistry
- 10 November 1995
Insight is provided into a new mechanism of autoregulation through signal transduction in prokaryotes and it is demonstrated that antimicrobial peptides can exert a second function as signaling molecules.
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium.
- M. Derrien, E. Vaughan, C. Plugge, W. D. de Vos
- BiologyInternational journal of systematic and…
- 1 September 2004
According to the data obtained in this work, strain MucT represents a novel bacterium belonging to a new genus in subdivision 1 of the Verrucomicrobia; the name Akkermansia muciniphila gen. nov., sp.