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Duodenal infusion of donor feces for recurrent Clostridium difficile.
TLDR
The infusion of donor feces was significantly more effective for the treatment of recurrent C. difficile infection than the use of vancomycin and patients showed increased fecal bacterial diversity, similar to that in healthy donors, with an increase in Bacteroidetes species and clostridium clusters IV and XIVa and a decrease in Proteobacteria species. Expand
Complete genome sequence of Lactobacillus plantarum WCFS1
TLDR
The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated from human saliva, has been determined, and contains 3,052 predicted protein-encoding genes, suggesting that these genes form a lifestyle adaptation region in the chromosome. Expand
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
TLDR
Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders. Expand
Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin.
TLDR
The kinetics, control, and efficiency of nisin-induced expression directed by the nisA promoter region were studied in Lactococcus lactis with transcriptional and translational fusions to the gusA reporter genes, illustrating the potential of the nisi-inducible expression system for overproduction of desired proteins. Expand
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
TLDR
Evidence is provided for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system, because of its crucial role in the host physiology and health status. Expand
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.
TLDR
Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased along with levels of butyrate-producing intestinal microbiota, and intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans. Expand
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium.
TLDR
According to the data obtained in this work, strain MucT represents a novel bacterium belonging to a new genus in subdivision 1 of the Verrucomicrobia; the name Akkermansia muciniphila gen. nov., sp. Expand
Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome.
TLDR
Global and deep molecular analysis of fecal samples indicates that patients with IBS have a different composition of microbiota, and correlation analysis of the microbial groups indicated the involvement of several groups of Firmicutes and Proteobacteria in the pathogenesis of IBS. Expand
Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.
TLDR
Transcription analyses of several L. lactis strains indicated that an expression product of the nisA gene, together with NisR, is required for the activation of nisinA transcription, indicating that NisI plays a role in the immunity mechanism. Expand
Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein
TLDR
It is concluded that the presence of SpaC is essential for the mucus interaction of L. rhamnosus GG and likely explains its ability to persist in the human intestinal tract longer than LC705 during an intervention trial. Expand
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