• Publications
  • Influence
Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study
BACKGROUND Guidelines suggest setting individualised targets for glycaemic control in elderly patients with type 2 diabetes, despite no evidence. We aimed to assess the feasibility of setting andExpand
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Ethnic differences in vascular stiffness and relations to hypertensive target organ damage
Objective People of Black African descent have greater risks of hypertensive target organ damage than would be anticipated for given levels of blood pressure. Arterial stiffness may further accountExpand
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Human endothelial function and microvascular ageing
Age is a primary risk factor for cardiovascular disease, and this is an increasingly important public health concern because of an increase in the absolute number and proportion of the population atExpand
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Diabetes, cardiovascular disease and the microcirculation
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for byExpand
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Clinical Inertia in Individualising Care for Diabetes: Is There Time to do More in Type 2 Diabetes?
Clinical inertia is defined as the failure to establish appropriate targets and escalate treatment to achieve treatment goals. It accounts for a significant proportion of failure to achieve targetsExpand
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The use of recombinant human B‐type natriuretic peptide (nesiritide) in the management of acute decompensated heart failure
  • W. D. Strain
  • Medicine
  • International journal of clinical practice
  • 1 November 2004
Nesiritide is a synthetic human B‐type natriuretic factor that has a balanced arterial and venous dilator effect, with natriuretic, diuretic, anti‐aldosterone and antisympathetic action. It wasExpand
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In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging.
Noninvasive, easy-to-use and accurate measurements of wall shear stress (WSS) in human blood vessels have always been challenging in clinical applications. Echo particle image velocimetry (Echo PIV)Expand
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Ranibizumab in Diabetic Macular Oedema – A Benefit–risk Analysis of Ranibizumab 0.5 mg PRN Versus Laser Treatment
Abstract Introduction: The structured Benefit–risk Action Team (BRAT) approach aims to assist healthcare decision makers in treatment assessments. We applied BRAT to compare the benefit–risk profileExpand
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Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage
Background People of Black African descent have increased risks of vascular target-organ damage not explained by greater blood pressures. Objective To study ethnic differences in theExpand
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Increased arterial stiffness in Europeans and African Caribbeans with type 2 diabetes cannot be accounted for by conventional cardiovascular risk factors.
BACKGROUND The impact of diabetes on vascular target organ damage (TOD) is not wholly explained by conventional risk factors. African Caribbeans have a greater prevalence of diabetes and some aspectsExpand
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