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STEROL METHYLTRANSFERASE 1 Controls the Level of Cholesterol in Plants
The side chain in plant sterols can have either a methyl or ethyl addition at carbon 24 that is absent in cholesterol. The ethyl addition is the product of two sequential methyl additions.Expand
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Insect Sterol Nutrition and Physiology: A Global Overview
Abstract Unlike most animals, insects lack the capacity to synthesize sterols that are required in lipid biostructures, as precursors to important steroid hormones and as regulators of developmentalExpand
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Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis.
Sterol 14alpha-demethylase encoded by CYP51 is a mixed-function oxidase involved in sterol synthesis in eukaryotic organisms. Completion of the Mycobacterium tuberculosis genome project revealed thatExpand
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Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei Published, JLR Papers in Press, November 26, 2006.
Trypanosoma brucei (TB) cultured in rat blood, bovine serum, or lipid-depleted serum generated distinct differences in cholesterol availability. Whereas cell proliferation of the parasite wasExpand
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Identification of natural RORγ ligands that regulate the development of lymphoid cells.
Mice deficient in the nuclear hormone receptor RORγt have defective development of thymocytes, lymphoid organs, Th17 cells, and type 3 innate lymphoid cells. RORγt binds to oxysterols derived fromExpand
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Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B
ABSTRACT Aspergillus fumigatus sterol 14-α demethylase (CYP51) isoenzymes A (AF51A) and B (AF51B) were expressed in Escherichia coli and purified. The dithionite-reduced CO-P450 complex for AF51A wasExpand
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Biosynthesis of Cholesterol and Other Sterols
  • W. D. Nes
  • Medicine
  • Chemical reviews
  • 8 September 2011
4.5. C24-Alkylation Reduction Bifurcation in Phytosterol Synthesis 6433 5. Sterol Enzyme Action 6434 5.1. C24 Methylation 6434 5.2. C24-Reduction 6438 5.3. Removal of Nuclear Methyl Groups at C4 6439Expand
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Sterol methyl transferase: enzymology and inhibition.
  • W. D. Nes
  • Medicine
  • Biochimica et biophysica acta
  • 2000
Sterol C-methylations catalyzed by the (S)-adenosyl-L-methionine: Delta(24)-sterol methyl transferase (SMT) have provided the focus for study of electrophilic alkylations, a reaction type ofExpand
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Sterol utilization and metabolism by Heliothis zea
Heliothis zea (corn earworm), an insect that fails to synthesize sterols de novo, was reared on an artificial diet treated with 18 different sterol supplements. Larvea did not develop on aExpand
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Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)
ABSTRACT Purified Candida albicans sterol 14-α demethylase (CaCYP51) bound the CYP51 substrates lanosterol and eburicol, producing type I binding spectra with Ks values of 11 and 25 μM, respectively,Expand
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